1. Recombinant Proteins
  2. TGFBR2/TGF-beta RII Protein, Mouse (HEK293, Fc)

TGFBR2/TGF-beta RII Protein, Mouse (HEK293, Fc)

Cat. No.: HY-P7427
Handling Instructions

TGFBR2/TGF-beta RII Protein, Mouse (HEK293, Fc), a fragment of transforming growth factor-beta receptor type 2 (TβRII), consists of amino acid of Ile24-Asp159 with a 6His tag at the C-terminus.

For research use only. We do not sell to patients.

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  • Technical Parameters

  • Properties

  • Documentation

TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II



HEK 293


Q62312-2 (I24-D184)

Gene ID


Molecular Weight

55-65 kDa

AA Sequence


Biological Activity
Data is not available.

Lyophilized powder.


Lyophilized after extensive dialysis against PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.


It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O or PBS.

Storage & Stability

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.


Room temperature in continental US; may vary elsewhere.


Transforming growth factor β (TGF-β) plays an important role in normal development and homeostasis. Dysregulation of TGF-β responsiveness and its downstream signaling pathways contribute to many diseases, including cancer initiation, progression, and metastasis. TGF-β ligands bind to three isoforms of the TGF-β receptor (TGFBR) with different affinities. TGFBRI and II are both serine/threonine and tyrosine kinases, but TGFBRIII does not have any kinase activity. Canonical TGF-β signaling occurs when one of the three ligands binds to TGFBRII, which then recruits and phosphorylates TGFBRI. TGFBRII is a 567 amino acid single-pass type I membrane protein that contains one protein kinase domain. The process of PTH1R-TGFBRII endocytosis was blocked using a Ser/Thr kinase-dead mutation of TGFBRII. TGFBRII directly phosphorylates proteins other than itself or TGFBRI[1][2].

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This equation is commonly abbreviated as: C1V1 = C2V2

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TGFBR2/TGF-beta RII Protein, Mouse (HEK293, Fc)
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