2. Gene
  3. Tgfbr2 - transforming growth factor, beta receptor II Gene

Tgfbr2 - transforming growth factor, beta receptor II Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as DNIIR; RIIDN; TBR-II; TbetaRII; TbetaR-II; 1110020H15Rik

Gene ID: 21813 | Gene type: protein coding

About Tgfbr2

Chromosome 9: 115,913,361-116,004,428 reverse strand.GRCm39:CM001002.3

This gene has 2 transcripts (splice variants), 263 orthologues, 11 paralogues and is associated with 41 phenotypes. Broad expression in lung adult (RPKM 56.6), subcutaneous fat pad adult (RPKM 56.5) and 23 other tissues.

Summary

Enables SMAD binding activity; transforming growth factor beta binding activity; and transforming growth factor beta-activated receptor activity. Involved in several processes, including animal organ development; circulatory system development; and positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and positive regulation of tolerance induction. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Used to study DiGeorge syndrome; Loeys-Dietz syndrome; cleft soft palate; and prostate Cancer. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 2; Marfan syndrome; gastrointestinal system Cancer (multiple); hereditary nonpolyposis colorectal Cancer type 6; and pancreatic Cancer. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tgfbr2 Products(2)

mRNA Protein Name
NM_029575.3 NP_083851.3 TGF-beta receptor type-2 isoform 2 precursor
NM_009371.3 NP_033397.3 TGF-beta receptor type-2 isoform 1 precursor

Tgfbr2 Protein Structure

ecTbetaR2

ecTbetaR2: pfam08917 (48 - 151)

STKc_TGFbR2_like

STKc_TGFbR2_like: cd14055 (247 - 541)

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  • 567 a.a.
Protein Preferred Names Protein Names

TGF-beta receptor type-2

TGF-beta receptor II

TGF-beta receptor type II

TGF-beta type II receptor

TGFR-2

transforming growth factor-beta receptor type II

Recombinant Tgfbr2 Proteins

Cat. No. Product Name Accession Purity
HY-P7427 TGFBR2/TGF-beta RII Protein, Mouse (HEK293, Fc) Q62312-2 (I24-D159) ≥95%
HY-P7428 TGFBR2/TGF-beta RII Protein, Mouse (HEK293, His) Q62312-2 (I24-D159) ≥95%
HY-P78801 TGFBR2/TGF-beta RII Protein, Mouse (Biotinylated, HEK293, His-Avi) Q62312 (I24-D184) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100115 TA-02 Inhibitor 99.57% Unkown
HY-137506 XST-14 99.69% Unkown
HY-RS14447 TGFBR2 Human Pre-designed siRNA Set A / Unkown
HY-RS14448 Tgfbr2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS14449 Tgfbr2 Rat Pre-designed siRNA Set A / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99963 Sudubrilimab Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tgfbr2 NCBI NCBI:7048
Rattus norvegicus Tgfbr2 NCBI NCBI:81810
Macaca mulatta Tgfbr2 NCBI NCBI:703088