Network Version
Amentoflavone Data Sheet
| Product Name: | Amentoflavone |
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| CAS No.: | 1617-53-4 | |
| Cat. No.: | HY-N0662 | |
| MWt: | 538.46 | |
| Formula: | C30H18O10 | |
| Purity : | >98% | |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) | |
| Mechanisms: | Target: Cancer Infection Inflammation/Immunology Neurological Disease | |
| Biological Activity: | ||
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Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase[1][2][3][4].
In Vitro: Amentoflavone (1-60 µM) inhibits the production of nitric oxide in a concentration-dependent manner in RAW 264.7 cells[2]. Amentoflavone (50-200 µM) inhibits the viability of U-87 MG cells with IC50 value of 100 µM at 48 h[3]. Amentoflavone (0, 50, 100 µM; 48 h) induces apoptosis and cell cycle arrest at sub-G1 phase[3]. Amentoflavone (0, 50, 100 µM; 48 h) inhibits NF-ĸB activation and decreases the expression of MCL1 and C-FLIP protein in U-87 MG cells[3]. Amentoflavone (0-32 µg/ml) shows antibacterial activity with MICs of 8, 4, 32, 8, 16, 8 µg/ml for E. faecium ATCC 19434, S. aureus ATCC 25923, S. mutans ATCC 3065, E. coli O-157 ATCC 25922, E. coli ATCC 43895, P. aeruginosa ATCC 27853, respectively[4]. In Vivo: Amentoflavone (25 mg/kg; p.o.; once a day for 3 consecutive days) shows neuroprotective role in epilepsy via anti-inflammatory effects in mouse[1]. |
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