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Aminoguanidine hydrochloride Data Sheet
| Product Name: | Aminoguanidine hydrochloride |
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| CAS No.: | 1937-19-5 | |
| Cat. No.: | HY-B1041 | |
| MWt: | 110.55 | |
| Formula: | CH7ClN4 | |
| Purity : | >98% | |
| Solubility: | H<sub>2</sub>O : ≥ 100 mg/mL;DMSO : 100 mg/mL (ultrasonic) | |
| Mechanisms: | Target: Inflammation/Immunology Metabolic Disease Neurological Disease | |
| Biological Activity: | ||
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Aminoguanidine (Pimagedine) hydrochloride is an inhibitor of diamine oxidase (DAO) and nitric oxide synthase (NOS). Aminoguanidine hydrochloride can reduce the formation of advanced glycation end products (AGEs). Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on Doxorubicin (HY-15142)-induced cell apoptosis. Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in the research of diabetic nephropathy[1][2][3][4][5].
In Vitro:Aminoguanidine (100, 200, 500, 1000 μM, 24 h) can reduce DOX-induced DNA damage and apoptosis in A549 cells [1]. Aminoguanidine (100 μM, 30 min) can induce ERK activation in AR42J cells and promote cell proliferation [2]. In Vivo:minoguanidine (50 mg/kg, Intraperitoneal injection ) protects mice from CCl4-induced hepatotoxicity[3]. Aminoguanidine (200 mg/kg, Single dose intraperitoneal injection) is protective against cyclophosphamide (CP) -induced oxidative stress and kidney damage in rats[4].br/> |
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