Network Version
Ascomycin Data Sheet
| Product Name: | Ascomycin |
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|---|---|---|
| CAS No.: | 104987-12-4 | |
| Cat. No.: | HY-13557 | |
| MWt: | 792.01 | |
| Formula: | C43H69NO12 | |
| Purity : | >98% | |
| Solubility: | DMSO : ≥ 39 mg/mL (49.24 mM) | |
| Mechanisms: | Target: Infection Inflammation/Immunology Neurological Disease | |
| Biological Activity: | ||
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Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research[1][2].
In Vitro: Ascomycin (FR-900520) suppresses immune response in vitro with an IC50 value of 0.55 nM for mouse mixed lymphocyte reaction[1]. Ascomycin is a powerful calcium-dependent serine/threonine protein phosphatase (calcineurin [CaN], protein phosphatase 2B) inhibitors. Its mechanism of action involves the formation of a molecular complex with the intracellular FK506-binding protein-12 (FKBP12), thereby acquiring the ability to interact with CaN and to interfere with the dephosphorylation of various substrates[3]. In Vivo: Ascomycin (FR-900520; i.m.; 0.32-32 mg/kg; 5 days a week; for 2 weeks) clearly prolongs skin allograft survival in rats[1]. |
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