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  3. Ascomycin

Ascomycin (Synonyms: Immunomycin; FR-900520; FK520)

Cat. No.: HY-13557 Purity: >98.0%
Handling Instructions

Ascomycin(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.

For research use only. We do not sell to patients.

Ascomycin Chemical Structure

Ascomycin Chemical Structure

CAS No. : 104987-12-4

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10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 72 In-stock
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100 mg USD 94 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Ascomycin purchased from MCE. Usage Cited in: MBio. 2017 Oct 24;8(5). pii: e01752-17.

    Deletion of the FKB1 gene of M. furfur confers resistance to FK506. Sensitivity of the M. furfur strain CBS 14141 to the calcineurin inhibitors FK506, Ascomycin, and Pimecrolimus.
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    Description

    Ascomycin(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. IC50 Value: 0.55 nM [1] Target: in vitro: When we used either CD4+CD8+ thymocytes or peripheral T cells activated by phorbol ester and ionomycin, the cell surface induction of CD5 was also partially blocked by CsA, FK-520 and rapamycin [2]. Ascomycinalso had a 3-fold lower immunosuppressive potency in a popliteal lymph node hyperplasia assay, resulting in an equivalent therapeutic index consistent with a common mechanistic dependence on calcineurin inhibition [3]. in vivo: In 14-day studies, nephrotoxicity was not induced by continuous i.p. infusion of ascomycin at 10 mg/kg/day or daily oral administration (up to 50 mg/kg/day) in rats on a normal diet, nor by continuous i.v. infusion (up to 6 mg/kg/day) in rats on a low salt diet to enhance susceptibility [3].

    Molecular Weight

    792.01

    Formula

    C₄₃H₆₉NO₁₂

    CAS No.

    104987-12-4

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 39 mg/mL (49.24 mM)

    H2O : < 0.1 mg/mL (insoluble)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.2626 mL 6.3131 mL 12.6261 mL
    5 mM 0.2525 mL 1.2626 mL 2.5252 mL
    10 mM 0.1263 mL 0.6313 mL 1.2626 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (3.16 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 2.5 mg/mL (3.16 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (3.16 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: >98.0%

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    Keywords:

    AscomycinImmunomycinFR-900520FK520FR900520FR 900520FK 520FK-520FKBPParasiteFK506-binding proteinInhibitorinhibitorinhibit

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    Product name:
    Ascomycin
    Cat. No.:
    HY-13557
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