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Auristatin F Data Sheet
| Product Name: | Auristatin F |
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|---|---|---|
| CAS No.: | 163768-50-1 | |
| Cat. No.: | HY-15583 | |
| MWt: | 745.99 | |
| Formula: | C40H67N5O8 | |
| Purity : | >98% | |
| Solubility: | DMSO : 200 mg/mL (268.10 mM; Need ultrasonic) | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
| Auristatin F is a potent cytotoxin in antibo-conjugated drugs and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) [1][2]. IC50 & Target:Microtubule[1] In Vitro:Auristatin F and Monomethyl Auristatin F (MMAF) are potent ADC cytotoxin used in antibody-drug conjugates[1]. In Vivo:Auristatin F (5 mg/kg; i.v.; male Sprague-Dawley rats) has Cmax of 8276.76 ng/mL. The AUClast is 65661.30 min*ng/mL, and the clearance (CL) is 77.33 mL/min/kg, which is above the hepatic blood flow in the rat[2]. | ||
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