1. Cell Cycle/DNA Damage
    Cytoskeleton
    Antibody-drug Conjugate/ADC Related
  2. Microtubule/Tubulin
    ADC Cytotoxin
  3. Auristatin F

Auristatin F 

Cat. No.: HY-15583 Purity: 97.51%
Handling Instructions

Auristatin F is a potent cytotoxin. Auristatin F, a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (ADC).

For research use only. We do not sell to patients.

Auristatin F Chemical Structure

Auristatin F Chemical Structure

CAS No. : 163768-50-1

Size Price Stock Quantity
1 mg USD 190 In-stock
Estimated Time of Arrival: December 31
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg USD 780 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

Auristatin F is a potent cytotoxin. Auristatin F, a potent microtubule inhibitor and vascular damaging agent (VDA), can be used in antibody-drug conjugates (ADC)[1].

IC50 & Target

Microtubule[1]

In Vitro

Auristatin F and Monomethyl Auristatin F (MMAF) are potent ADC cytotoxin used in antibody-drug conjugates[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

745.99

Formula

C₄₀H₆₇N₅O₈

CAS No.

163768-50-1

SMILES

CC(C)[[email protected]](N(C)C)C(N[[email protected]](C(N([[email protected]@H]([[email protected]@H](C)CC)[[email protected]@H](CC(N1CCC[[email protected]@]1([H])[[email protected]](OC)[[email protected]@H](C)C(N[[email protected]](C(O)=O)CC2=CC=CC=C2)=O)=O)OC)C)=O)C(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 56 mg/mL (75.07 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3405 mL 6.7025 mL 13.4050 mL
5 mM 0.2681 mL 1.3405 mL 2.6810 mL
10 mM 0.1341 mL 0.6703 mL 1.3405 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 97.51%

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Keywords:

Auristatin FMicrotubule/TubulinADC CytotoxinConjugateinhibitorcytotoxinmicrotubulevasculardamagingagentVDAInhibitorinhibit

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Product Name:
Auristatin F
Cat. No.:
HY-15583
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