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BAY-876 Data Sheet
| Product Name: | BAY-876 |
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|---|---|---|
| CAS No.: | 1799753-84-6 | |
| Cat. No.: | HY-100017 | |
| MWt: | 496.42 | |
| Formula: | C24H16F4N6O2 | |
| Purity : | >98% | |
| Solubility: | Methanol : 1 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : ≥ 100 mg/mL | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
| BAY-876 is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis[1][2][3]. IC50 & Target:IC50: 2 nM (GLUT1)[1] In Vitro:BAY-876 (25-75 nM; 24 and 72 hours) has the growth-inhibitory effect and leads to a dose-dependent decrease in numbers of SKOV-3 and OVCAR-3 cells[2]. In Vivo:BAY-876 (oral administration; 1.5-4.5 mg/kg/day for 28 days) causes a clear dose-dependent inhibition of tumorigenicity in mice[2]. | ||
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