Network Version
Calicheamicin Data Sheet
| Product Name: | Calicheamicin |
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|---|---|---|
| CAS No.: | 108212-75-5 | |
| Cat. No.: | HY-19609 | |
| MWt: | 1368.35 | |
| Formula: | C55H74IN3O21S4 | |
| Purity : | >98% | |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) | |
| Mechanisms: | Target: Cancer Infection | |
| Biological Activity: | ||
| Calicheamicin, an antitumor antibiotic, is a cytotoxic agent that causes double-strand DNA breaks. Calicheamicin is a DNA synthesis inhibitor[1]. In Vitro:CMC-544, consisting of a humanized CD22 Ab linked to calicheamicin, is effective in pediatric primary B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells in vitro. CMC-544 induces cell death in various ALL cell lines in a dose- and time-dependent way, with IC50 values ranging from 0.15 to 4.9 ng/mL. CMC-544 (10 ng/mL) is effective and specific in primary BCP-ALL cells[2]. In Vivo:An ADC comprising a humanized anti-EFNA4 monoclonal antibody conjugated to the DNA-damaging agent calicheamicin achieves sustained tumor regressions in both TNBC and ovarian cancer PDX in vivo. PF-06647263 (0.27, 0.36 mg/kg) results in significant tumor regressions in TNBC xenografts[1]. | ||
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