Network Version
Chlorogenic acid Data Sheet
| Product Name: | Chlorogenic acid |
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| CAS No.: | 327-97-9 | |
| Cat. No.: | HY-N0055 | |
| MWt: | 354.31 | |
| Formula: | C16H18O9 | |
| Purity : | >98% | |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H<sub>2</sub>O : ≥ 20 mg/mL | |
| Mechanisms: | Target: Cancer Cardiovascular Disease Infection Inflammation/Immunology | |
| Biological Activity: | ||
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Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound[1][2][3].
In Vitro: Chlorogenic acid (10 μM, 16 h) decreases HIF-1α protein levels in CoCl2 induced hypoxic A549 cells, but does not affect HIF-1α mRNA level[1]. Chlorogenic acid (10 μM, 24 h) inhibits the hypoxia-induced HUVEC cell migration, invasion and tube formation of vascular endothelial cells[1]. Chlorogenic acid (25, 50 μM, 24 h) inhibits cell proliferation of Huh7 cells, and reduces the number of invading and migrating cells[4]. In Vivo: Chlorogenic acid (10 μM, s.c.) inhibits VEGF (200 ng/mL)-induced angiogenesis in C57BL/6J mice, by suppression of AKT activation (Matrigel plug assay)[1]. Chlorogenic acid (10-100 mg/kg, p.o.) shows protective effects against experimental reflux esophagitis in rats[3]. Chlorogenic acid (10 mg/kg, i.v.) prevents endotoxic mortality and induced TNF-α release of LPS-intoxicated C57BL/6 mice, and ameliorates acute liver injury of LPS/GalN-challenged mice[2]. Chlorogenic acid (ip, 25-200 mg/kg) inhibits tumor growth in NOD/SCID mice inoculated with Huh7 or H446 cells[4]. |
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