Network Version
D-64131 Data Sheet
| Product Name: | D-64131 |
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|---|---|---|
| CAS No.: | 74588-78-6 | |
| Cat. No.: | HY-15482 | |
| MWt: | 251.28 | |
| Formula: | C16H13NO2 | |
| Purity : | >98% | |
| Solubility: | DMSO : ≥ 100 mg/mL (397.96 mM) | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
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D-64131 is an orally active tubulin inhibitor, with an IC50 of 0.53 μM for tubulin polymerization. D-64131 has antimitotic activity. D-64131 can be used for cancer research[1][2].
IC50 & Target: IC50: 0.53 μM (tubulin polymerization)[2]
In Vitro: D-64131 is antimitotic by binding to β-tubulin, thereby destabilizing microtubules and arresting mitotic cells in the M-phase[1]. D-64131 inhibits the proliferation of tumor cells from 12 of 14 different organs and tissues with mean IC50s of 62 nM[1]. D-64131 is cytotoxic toward MDR/MRP tumor cell lines[1]. D-64131 suppresses U373 proliferation and cell cycle with IC50s of 74 nM and 62.7nM, respectively[2]. In Vivo: D-64131 (200-400 mg/kg; p.o.; daily; days 1-5, 8-9, and 15-18) significantly inhibits tumor growth in the human amelanoic melanoma MEXF 989 tumor xenograft mice model[1]. D-64131 has oral bioavailability and is well tolerated at efficacious doses[1]. |
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