1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin

D-64131 

Cat. No.: HY-15482 Purity: 99.42%
Data Sheet SDS Handling Instructions

D-64131 is a novel inhibitor of Tubulin polymerization that competitively binds with [(3)H]colchicine to αβ-Tubulin.

For research use only. We do not sell to patients.
D-64131 Chemical Structure

D-64131 Chemical Structure

CAS No. : 74588-78-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $97 In-stock
10 mg $88 In-stock
50 mg $385 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

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Description

D-64131 is a novel inhibitor of Tubulin polymerization that competitively binds with [(3)H]colchicine to αβ-Tubulin. IC50 Value: N/A Target: Microtubule/Tubulin in vitro: D-64131 is cytotoxic and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). D-64131 prevents growth of tumor models in mice following oral administration in vivo. D-64131 has significant potential in cancer treatment. The proliferation of tumor cells from 12 of 14 different organs and tissues was inhibited with mean IC(50)s of 62 nM by D-64131. in vivo: In animal studies, no signs of systemic toxicity were observed after p.o. dosages of up to 400 mg/kg of D-64131. In xenograft experiments with the human amelanoic melanoma MEXF 989, D-64131 was highly active with treatment resulting in a growth delay of 23.4 days at 400 mg/kg. Therefore, D-64131 and analogues have the potential to be developed for cancer therapy, replacing or supplementing standard therapy regimens with tubulin-targeting drugs from natural sources.

References
Molecular Weight

251.28

Formula

C₁₆H₁₃NO₂

CAS No.

74588-78-6

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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D-64131
Cat. No.:
HY-15482
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