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Products are for research use only. Not for human use. We do not sell to patients.
(D 64131; D64131)
D-64131 Chemical Structure
|Product name: D-64131|
|Cat. No.: HY-15482|
D-64131 is a novel inhibitor of Tubulin polymerization that competitively binds with [(3)H]colchicine to αβ-Tubulin.
IC50 Value: N/A
in vitro: D-64131 is cytotoxic and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). D-64131 prevents growth of tumor models in mice following oral administration in vivo. D-64131 has significant potential in cancer treatment. The proliferation of tumor cells from 12 of 14 different organs and tissues was inhibited with mean IC(50)s of 62 nM by D-64131.
in vivo: In animal studies, no signs of systemic toxicity were observed after p.o. dosages of up to 400 mg/kg of D-64131. In xenograft experiments with the human amelanoic melanoma MEXF 989, D-64131 was highly active with treatment resulting in a growth delay of 23.4 days at 400 mg/kg. Therefore, D-64131 and analogues have the potential to be developed for cancer therapy, replacing or supplementing standard therapy regimens with tubulin-targeting drugs from natural sources.
|M.Wt||251.28||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
10 mM in DMSO
|1 mg||5 mg||10 mg|
|1 mM||3.9796 mL||19.8981 mL||39.7962 mL|
|5 mM||0.7959 mL||3.9796 mL||7.9592 mL|
|10 mM||0.3980 mL||1.9898 mL||3.9796 mL|
. Mahboobi, Siavosh; Pongratz, Herwig; Hufsky, Harald et al. Synthetic 2-Aroylindole Derivatives as a New Class of Potent Tubulin-Inhibitory, Antimitotic Agents. Journal of Medicinal Chemistry (2001), 44(26), 4535-4553.
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