1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. D-64131

D-64131 

Cat. No.: HY-15482 Purity: 99.17%
Handling Instructions

D-64131 is an orally active tubulin inhibitor, with an IC50 of 0.53 μM for tubulin polymerization. D-64131 has antimitotic activity. D-64131 can be used for cancer research.

For research use only. We do not sell to patients.

D-64131 Chemical Structure

D-64131 Chemical Structure

CAS No. : 74588-78-6

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 97 In-stock
Estimated Time of Arrival: December 31
10 mg USD 88 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

D-64131 is an orally active tubulin inhibitor, with an IC50 of 0.53 μM for tubulin polymerization. D-64131 has antimitotic activity. D-64131 can be used for cancer research[1][2].

IC50 & Target

IC50: 0.53 μM (tubulin polymerization)[2]

In Vitro

D-64131 is antimitotic by binding to β-tubulin, thereby destabilizing microtubules and arresting mitotic cells in the M-phase[1].
D-64131 inhibits the proliferation of tumor cells from 12 of 14 different organs and tissues with mean IC50s of 62 nM[1].
D-64131 is cytotoxic toward MDR/MRP tumor cell lines[1].
D-64131 suppresses U373 proliferation and cell cycle with IC50s of 74 nM and 62.7nM, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: HeLa/KB cervical carcinoma cells
Concentration: 1 nM-1 μM
Incubation Time: 48 hours
Result: Induced dose-dependently arrested in G2-M before induction of apoptotic cell death.
In Vivo

D-64131 (200-400 mg/kg; p.o.; daily; days 1-5, 8-9, and 15-18) significantly inhibits tumor growth in the human amelanoic melanoma MEXF 989 tumor xenograft mice model[1].
D-64131 has oral bioavailability and is well tolerated at efficacious doses[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Outbred nude mice (6-8 weeks), human amelanoic melanoma MEXF 989 tumor xenograft model[1]
Dosage: 200 mg/kg, 400 mg/kg
Administration: Oral administration, daily, on days 1-5, 8-9, and 15-18 after xenograft
Result: Resulted in significant tumor growth inhibition during treatment.
Molecular Weight

251.28

Formula

C₁₆H₁₃NO₂

CAS No.

74588-78-6

SMILES

O=C(C(N1)=CC2=C1C=CC(OC)=C2)C3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (397.96 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9796 mL 19.8981 mL 39.7962 mL
5 mM 0.7959 mL 3.9796 mL 7.9592 mL
10 mM 0.3980 mL 1.9898 mL 3.9796 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

D-64131D64131D 64131Microtubule/Tubulinantimitoticactivityantiproliferativetubulin-inhibitorycytotoxicityastrocytomacarcinomaG2/MphaseInhibitorinhibitorinhibit

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D-64131
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HY-15482
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