74588-78-6
74588-78-6
Chemical Structure
D-64131
- CAS No.: 74588-78-6
- Formula:C16H13NO2
- Molecular Weight:251.28
IUPAC Name: (5-methoxy-1H-indol-2-yl)(phenyl)methanone
InChIKey: ICMIJSRDISNKOC-UHFFFAOYSA-N
SMILES: O=C(C(N1)=CC2=C1C=CC(OC)=C2)C3=CC=CC=C3
Biological Activity: D-64131 is an orally active tubulin inhibitor, with an IC50 of 0.53 μM for tubulin polymerization. D-64131 has antimitotic activity. D-64131 can be used for cancer research[1][2].
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D-64131 | 99.68% | D-64131 is an orally active tubulin inhibitor, with an IC50 of 0.53 μM for tubulin polymerization. D-64131 has antimitotic activity. D-64131 can be used for cancer research. | ||||||||||||||||||||
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References
- [1]. Thomas Beckers, et al. 2-Aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Research (2002), 62(11), 3113-3119. [Content Brief]
- [2]. S Mahboobi, et al. Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents. J Med Chem. 2001 Dec 20;44(26):4535-53. [Content Brief]
Keywords
