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Eleutheroside E Data Sheet
| Product Name: | Eleutheroside E |
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|---|---|---|
| CAS No.: | 39432-56-9 | |
| Cat. No.: | HY-N0272 | |
| MWt: | 742.72 | |
| Formula: | C34H46O18 | |
| Purity : | >98% | |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H<sub>2</sub>O : 1 mg/mL (ultrasonic) | |
| Mechanisms: | Target: Inflammation/Immunology Neurological Disease | |
| Biological Activity: | ||
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Eleutheroside E is an important component of ginseng that can be taken orally. Eleutheroside E has anti-inflammatory and antioxidant properties, and it helps reduce apoptosis in heart cells caused by hypoxia-reoxygenation (H/R) damage. Eleutheroside E can improve type 2 diabetes, enhance cognitive function, and has neuroprotective effects[1][2][3][4].
In Vitro:Eleutheroside E (10 μM, 24 h) increases insulin-induced glucose uptake in C2C12 myotubes and improves the inhibition of glucose uptake by TNF-α in 3T3-L1 adipocytes[1]. Eleutheroside E (0-100 μM, 3 h) enhances cell viability in H9c2 cells subjected to H/R injury[2]. Eleutheroside E (0-100 μM, 12 h) has a protective effect against apoptosis in H9c2 cells induced by H/R injury[2]. Eleutheroside E (100 μM, 12 h) boosts antioxidant capacity in H9c2 cells[2]. Eleutheroside E (100 μM, 12 h) blocks the MAPK pathway and inhibits the activation of NF-κB[2]. In Vivo:Eleutheroside E (0.003%, oral, daily, for five weeks) improves liver glucose metabolism in obese type 2 diabetes mice by upregulating glycolysis and downregulating gluconeogenesis[1]. Eleutheroside E (15-60 mg/kg, oral, once daily, three weeks) alleviates arthritis in a collagen-induced arthritis mouse model[3]. Eleutheroside E (50 mg/kg, oral, once daily, four weeks) prevents cognitive deficits caused by radiation in mice[4]. |
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