Network Version
IFN alpha-IFNAR-IN-1 hydrochloride Data Sheet
| Product Name: | IFN alpha-IFNAR-IN-1 hydrochloride |
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| CAS No.: | 2070014-98-9 | |
| Cat. No.: | HY-12836A | |
| MWt: | 315.86 | |
| Formula: | C18H18ClNS | |
| Purity : | >98% | |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H<sub>2</sub>O : 16.67 mg/mL (ultrasonic) | |
| Mechanisms: | Target: Inflammation/Immunology | |
| Biological Activity: | ||
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IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits modified Vaccinia virus ankara (MVA)-induced IFN-α responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) (IC50=2-8 μM)[1].
In Vitro:IFN alpha-IFNAR-IN-1 (compound 1) (18 μM; 24 h) hydrochloride specifically inhibits MVA-induced IFN-a responses by BMpDCs[1]. |
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