Network Version
Indoximod Data Sheet
| Product Name: | Indoximod |
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|---|---|---|
| CAS No.: | 110117-83-4 | |
| Cat. No.: | HY-16724 | |
| MWt: | 218.26 | |
| Formula: | C12H14N2O2 | |
| Purity : | >98% | |
| Solubility: | DMSO : 0.55 mg/mL (ultrasonic;warming);H<sub>2</sub>O : 5 mg/mL (ultrasonic;adjust pH to 2 with HCl) | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
| Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer[1][2]. IC50 & Target: Ki: 19 μM (IDO)[2] In Vitro: The IDO inhibitor 1-methyl-tryptophan exists in two stereoisomers with potentially different biological properties. The L isomer is the more potent inhibitor of IDO activity using the purified enzyme and in HeLa cell–based assays. However, the D isomer is significantly more effective in reversing the suppression of T cells created by IDO-expressing dendritic cells. The L isomer of 1-methyl-tryptophan functioned as a competitive inhibitor (Ki=19 μM), whereas the d isomer is much less effective. The DL mixture is intermediate, with a Ki of 35 μM[1]. In Vivo: The D isomer is more efficacious as an anticancer agent in chemo-immunotherapy regimens using NSC-26271, NSC 125973, or LY 188011, when tested in mouse models of transplantable melanoma and transplantable and autochthonous breast cancer. The D isomer of 1-methyl-tryptophan specifically targets the IDO gene because the antitumor effect of d-1-methyl-tryptophan is completely lost in mice with a disruption of the IDO gene (IDO-knockout mice). Oral administration of dl-1-methyl-tryptophan in combination with NSC 125973 can elicit regression of autochthonous breast tumors[1]. | ||
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