Network Version
Itacitinib Data Sheet
| Product Name: | Itacitinib |
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|---|---|---|
| CAS No.: | 1334298-90-6 | |
| Cat. No.: | HY-16997 | |
| MWt: | 553.51 | |
| Formula: | C26H23F4N9O | |
| Purity : | >98% | |
| Solubility: | DMSO : ≥ 30 mg/mL | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
| Itacitinib (INCB039110) is an orally active and selective inhibitor of JAK1 with an IC50 of 2 nM for human JAK1. Itacitinib shows >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2; Itacitinib is used in the research of myelofibrosis[1][2]. IC50 & Target: JAK[1] In Vitro: Itacitinib (INCB039110) is a potent and selective inhibitor of JAK1, with >20-fold selectivity for JAK1 over JAK2 and >100-fold over JAK3 and TYK2. Itacitinib is used in the research of myelofibrosis[1]. | ||
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