Network Version
Maytansinol Data Sheet
| Product Name: | Maytansinol |
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|---|---|---|
| CAS No.: | 57103-68-1 | |
| Cat. No.: | HY-19474 | |
| MWt: | 565.06 | |
| Formula: | C28H37ClN2O8 | |
| Purity : | >98% | |
| Solubility: | DMSO : ≥ 35 mg/mL | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
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Maytansinol (Ansamitocin P-0) is a derivative of Maytansine. Maytansinol can inhibit tubulin polymerization and induce apoptosis. Maytansinol has antitumor activity. Maytansinol can be used in cancer drug research[1][2].
In Vitro:Maytansinol (0.09-0.75 nM, 24 h) decreases the growth and survival of HCT116 cells in a dose-dependent manner [2]. In Vivo:Maytansinol (2 μM, 10 μM, add to food, 1-2 h) can depolymerize microtubules in Drosophila. Maytansinol (0.5-2 μM, add to food, 10 days) decreases the survival rate of wild-type and p53 mutant larvae. Maytansinol (1 or 2 μM, add to food, 24-26 h) can induce apoptosis of wild-type Drosophila cells[2]. |
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