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Signaling Pathway

Maytansinol

HY-19474

(Ansamitocin P-0)

Maytansinol

Maytansinol Chemical Structure

Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro.

Size Price Stock Quantity
10 mM * 1 mL in DMSO $112 In-stock
5 mg $90 In-stock
10 mg $150 In-stock
50 mg $450 In-stock
100 mg Get quote
200 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €110 In-stock
5 mg €88 In-stock
10 mg €147 In-stock
50 mg €441 In-stock
100 mg Get quote
200 mg Get quote

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Product name: Maytansinol
Cat. No.: HY-19474

Maytansinol Data Sheet

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of Maytansinol

Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro.
Target: Microtubule/Tubulin
in vitro: Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to drug.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 565.06 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₂₈H₃₇ClN₂O₈
CAS No 57103-68-1
Solvent & Solubility

DMSO: ≥ 35 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.7697 mL 8.8486 mL 17.6972 mL
5 mM 0.3539 mL 1.7697 mL 3.5394 mL
10 mM 0.1770 mL 0.8849 mL 1.7697 mL

References on Maytansinol

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