1. Antibody-drug Conjugate/ADC Related
    Cell Cycle/DNA Damage
    Cytoskeleton
  2. ADC Cytotoxin
    Microtubule/Tubulin

Maytansinol (Synonyms: Ansamitocin P-0)

Cat. No.: HY-19474
Handling Instructions

Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro.

For research use only. We do not sell to patients.
Maytansinol Chemical Structure

Maytansinol Chemical Structure

CAS No. : 57103-68-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO $112 In-stock
5 mg $90 In-stock
10 mg $150 In-stock
50 mg $450 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro. Target: Microtubule/Tubulin in vitro: Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to drug.

Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.7697 mL 8.8486 mL 17.6972 mL
5 mM 0.3539 mL 1.7697 mL 3.5394 mL
10 mM 0.1770 mL 0.8849 mL 1.7697 mL
M.Wt

565.06

Formula

C₂₈H₃₇ClN₂O₈

CAS No.

57103-68-1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 35 mg/mL

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Product Name:
Maytansinol
Cat. No.:
HY-19474
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