Network Version
Tetrahydroxyquinone Data Sheet
| Product Name: | Tetrahydroxyquinone |
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| CAS No.: | 319-89-1 | |
| Cat. No.: | HY-B1106 | |
| MWt: | 172.09 | |
| Formula: | C6H4O6 | |
| Purity : | >98% | |
| Solubility: | DMSO : 100 mg/mL (581.09 mM; Need ultrasonic); H2O : 1 mg/mL (5.81 mM; ultrasonic and warming and heat to 80°C) | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
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Tetrahydroxyquinone (Tetrahydroxy-1,4-benzoquinone), a primitive anticataract agent, is a redox active benzoquinone. Tetrahydroxyquinone can take part in a redox cycle with semiquinone radicals, leading to the formation of reactive oxygen species (ROS)[1].
In Vitro: Tetrahydroxyquinone (100-500 μM; 24 hours; HL60 cells) treatment shows cytotoxic for HL60 leukaemia cells by total protein content (IC50 of 20 µM), phosphatase activity (IC50 of 40 µM), or by MTT assay (IC50 of 45 µM). Tetrahydroxyquinone is an efficient inducer of ROS production in HL60 leukaemia cells[1]. Tetrahydroxyquinone efficiently activates caspase 3 in concentration in excess of 25 µM, stimulates DNA fragmentation at the same concentration and provoke phosphatidylserine exposure[1]. Tetrahydroxyquinone induces the release of cytochrome c from the mitochondria at concentration as low as 25 µM. Tetrahydroxyquinone treatment also causes increase of phosphorylation of Ser473 in protein kinase B (the Bad kinase for Ser112)[1]. |
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