1. Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
    Apoptosis
  2. Reactive Oxygen Species
    Apoptosis
  3. Tetrahydroxyquinone

Tetrahydroxyquinone (Synonyms: Tetrahydroxy-1,4-benzoquinone; Tetrahydroxybenzoquinone)

Cat. No.: HY-B1106 Purity: ≥95.0%
Handling Instructions

Tetrahydroxyquinone (Tetrahydroxy-1,4-benzoquinone), a primitive anticataract agent, is a redox active benzoquinone. Tetrahydroxyquinone can take part in a redox cycle with semiquinone radicals, leading to the formation of reactive oxygen species (ROS).

For research use only. We do not sell to patients.

Tetrahydroxyquinone Chemical Structure

Tetrahydroxyquinone Chemical Structure

CAS No. : 319-89-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Tetrahydroxyquinone (Tetrahydroxy-1,4-benzoquinone), a primitive anticataract agent, is a redox active benzoquinone. Tetrahydroxyquinone can take part in a redox cycle with semiquinone radicals, leading to the formation of reactive oxygen species (ROS)[1].

In Vitro

Tetrahydroxyquinone (100-500 μM; 24 hours; HL60 cells) treatment shows cytotoxic for HL60 leukaemia cells by total protein content (IC50 of 20 µM), phosphatase activity (IC50 of 40 µM), or by MTT assay (IC50 of 45 µM). Tetrahydroxyquinone is an efficient inducer of ROS production in HL60 leukaemia cells[1].
Tetrahydroxyquinone efficiently activates caspase 3 in concentration in excess of 25 µM, stimulates DNA fragmentation at the same concentration and provoke phosphatidylserine exposure[1].
Tetrahydroxyquinone induces the release of cytochrome c from the mitochondria at concentration as low as 25 µM. Tetrahydroxyquinone treatment also causes increase of phosphorylation of Ser473 in protein kinase B (the Bad kinase for Ser112)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HL60 leukaemia cells
Concentration: 100 μM, 200 μM, 300 μM, 400 μM, 500 μM
Incubation Time: 24 hours
Result: Showed cytotoxic for HL60 leukaemia cells.
Molecular Weight

172.09

Formula

C₆H₄O₆

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (581.09 mM; Need ultrasonic)

H2O : 1 mg/mL (5.81 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8109 mL 29.0546 mL 58.1091 mL
5 mM 1.1622 mL 5.8109 mL 11.6218 mL
10 mM 0.5811 mL 2.9055 mL 5.8109 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (14.53 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (14.53 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Tetrahydroxyquinone
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