Network Version
Thiostrepton Data Sheet
| Product Name: | Thiostrepton |
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|---|---|---|
| CAS No.: | 1393-48-2 | |
| Cat. No.: | HY-B0990 | |
| MWt: | 1664.89 | |
| Formula: | C72H85N19O18S5 | |
| Purity : | >98% | |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) | |
| Mechanisms: | Target: Infection | |
| Biological Activity: | ||
| Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation[1]. In Vitro: Thiostrepton (0.01-1000 μM; 48 hours) suppresses cell viability in A2780 and HEC-1A[2]. In Vivo: Thiostrepton (i.p.; 17 mg/kg) reduces the tumorigenicity of Ewing's sarcoma (EWS) cells. Tumor volumes in control mice have increased ~6-fold from the initiation of treatment, while their Thiostrepton-treated counterparts increase only ~1.7-fold, exhibiting a ~3.5-fold reduction, relative to controls[3]. | ||
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