Network Version
Trioxsalen Data Sheet
| Product Name: | Trioxsalen |
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| CAS No.: | 3902-71-4 | |
| Cat. No.: | HY-B1157 | |
| MWt: | 228.247 | |
| Formula: | C14H12O3 | |
| Purity : | >98% | |
| Solubility: | DMSO : 2 mg/mL (ultrasonic);H<sub>2</sub>O : 1 mg/mL (ultrasonic;warming;heat to 80°C) | |
| Mechanisms: | Target: Inflammation/Immunology | |
| Biological Activity: | ||
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Trioxsalen (Trisoralen), a psoralen derivative, is a photochemical DNA crosslinker. Trioxsalen only works after photoactivation with near ultraviolet light. Trioxsalen is a photosensitizer that can be used for the research of vitiligo and hand eczema. Trioxsalen is used for visualization of genomic interstrand cross-links localized by laser photoactivation[1][2][3].
In Vitro: Trioxsalen (200 nM) plus 365 nm light produce DNA crosslinks but not breaks in mouse L1210 leukemia cells[4]. Trioxsalen/UVA treatment of HaCaT keratinocytes induces NF-kappaB binding activity, and that this is a synergistic effect[5]. Trioxsalen shows anti-inflammatory capacities in vitro[5]. In Vivo: Trioxsalen induces dose-dependent depletion of ATPase-positive LCs, with a maximal depletion of 80%, in oral mucous membrane (OMM) with PUVA (UVA doses of 1-8 J/cm2) in rat[3]. |
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