Network Version
Vinblastine sulfate Data Sheet
| Product Name: | Vinblastine sulfate |
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|---|---|---|
| CAS No.: | 143-67-9 | |
| Cat. No.: | HY-13780 | |
| MWt: | 909.0526 | |
| Formula: | C46H60N4O13S | |
| Purity : | >98% | |
| Solubility: | DMSO : ≥ 44 mg/mL (48.40 mM) | |
| Mechanisms: | Target: Cancer | |
| Biological Activity: | ||
| Vinblastine sulfate is a cytotoxic alkaloid used against various cancer types. Vinblastine sulfate inhibits the formation of microtubule and suppresses nAChR with an IC50 of 8.9 μM. IC50 & Target: IC50: 8.9 μM(nAChR)[1] In Vitro: Vinblastine does not depolymerize spindle microtubules, yet it powerfully blocks mitosis (for example, IC50 0.8 nM in HeLa cells) and cells die by apoptosis[2]. In NB4 cells, vinblastine produces alteration of p53 and DNA fragmentation. Vinblastine treatment has an antiproliferative effect via the induction of apoptosis producing Bax/Bcl-2 imbalance. Vinblastine treatment suppresses NFκB expression and depresses NFκB-DNA binding activity while maintaining JNK activation that subsequently results in apoptotic response through caspase-dependent pathway[3]. Vinblastine is found to trigger apoptosis as evidenced by the loss of mitochondrial membrane potential, the release of both cytochrome c and apoptosis inducing factor, activation of caspase-9 and 3, and cleavage of Poly (ADP-ribose)-Polymerase[4]. In Vivo: Vinblastine is a widely used anticancer drug with undesired side effects. Its conjugation with carrier molecules could be an efficient strategy to reduce these side effects[5]. | ||
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