Network Version
Product Name: | Vinorelbine ditartrate | |
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CAS No.: | 125317-39-7 | |
Cat. No.: | HY-12053A | |
MWt: | 1079.11 | |
Formula: | C53H66N4O20 | |
Purity : | >98% | |
Solubility: | DMSO : ≥ 100 mg/mL (92.67 mM); H2O : ≥ 100 mg/mL (92.67 mM) | |
Mechanisms: | Target: Cancer | |
Biological Activity: | ||
Vinorelbine (ditartrate) is an anti-mitotic agent which inhibits the proliferation of Hela cells with IC50 of 1.25 nM. In Vitro: Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC50) at concentrations of 1.25 nM. At concentration of 8 nM vinorelbine, no cells are in anaphase[1]. Vinorelbine time-dependently induces the p53 and p21WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine stimulates reporter genes in a concentration-dependent manner[2]. In Vivo: After vinorelbine treatment, the first neutropenicepisode occurred after the first (4 dogs), second (1), or sixth(1) vinorelbine treatment in the dogs[3]. Vinorelbine is tolerated at a weekly interval in tumor-bearing cats, with an MTD of 11.5 mg/m2[4]. |
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