Network Version
Cisapride Data Sheet
| Product Name: | Cisapride |
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|---|---|---|
| CAS No.: | 81098-60-4 | |
| Cat. No.: | HY-14149 | |
| MWt: | 465.95 | |
| Formula: | C23H29ClFN3O4 | |
| Purity : | >98% | |
| Solubility: | H<sub>2</sub>O : 0.1 mg/mL (ultrasonic;warming);DMSO : 100 mg/mL (ultrasonic) | |
| Mechanisms: | Target: Neurological Disease | |
| Biological Activity: | ||
| Cisapride (R 51619) is an orally active 5-HT4 receptor agonist with an EC50 value of 140 nM. Cisapride is a hERG blocker with an IC50 value of 9.4 nM. Cisapride is a gastroprokinetic agent that stimulates gastrointestinal motor activity[1][2][3][4]. In Vitro:Cisapride (1-100 nM) is a potent hERG blockers with an IC50 value of 9.4 nM[1]. Cisapride (1-100 nM) shows efficacy to 5-HT4 receptor with an EC50 value of 140 nM[1]. Cisapride (0.3, 1, 3, 10 and 30 μM) dose-dependently inhibits Kv4.3 with an IC50 value of 9.8 μM in Kv4.3 potassium channels expressing CHO cells[2]. In Vivo:Cisapride (0.1-1 mg/kg; i.v., once) stimulates antral and colonic motility in conscious dogs[3]. Cisapride (2 mg/kg (i.p.); 4 mg/kg, (oral administration); once) shows no significant differences in macroscopic features, histopathological features, cytokines profile and bodyweight changes with TNBS-treated rats[4]. | ||
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