Network Version
Elacridar hydrochloride Data Sheet
| Product Name: | Elacridar hydrochloride |
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| CAS No.: | 143851-98-3 | |||||||||||||||||||||||||
| Cat. No.: | HY-50880 | |||||||||||||||||||||||||
| MWt: | 600.1 | |||||||||||||||||||||||||
| Formula: | C34H34ClN3O5 | |||||||||||||||||||||||||
| Purity : | >98% | |||||||||||||||||||||||||
| Solubility: | DMSO : 62.5 mg/mL (104.15 mM; Need ultrasonic); H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble) | |||||||||||||||||||||||||
| Mechanisms: | Target: Cancer | |||||||||||||||||||||||||
| Biological Activity: | ||||||||||||||||||||||||||
Elacridar hydrochloride (GF120918A) is an orally active P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) inhibitor. Elacridar hydrochloride can be used to examine the influence of efflux transporters on drug distribution to brain and it can be used for the research of cancer[1][2].
In Vitro: Elacridar hydrochloride (0.001-1 μM; 2 h) inhibits cell viability of 786-O cells[2].
Elacridar hydrochloride (5 μM; 24 h) affects P-glycoprotein and ABCG2 protein expression levels in MCF-7 and 786-O cell lines[2].
Elacridar hydrochloride (5 μM; 24 h) affects 99mTc-MIBI intracellular accumulation in MCF-7 and 786-O cells[2].
In Vivo: Elacridar hydrochloride (100 mg/kg; i.p. once) shows different distribution in brain and plasma[1].
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