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Mefenamic acid Data Sheet
| Product Name: | Mefenamic acid |
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|---|---|---|
| CAS No.: | 61-68-7 | |
| Cat. No.: | HY-B0574 | |
| MWt: | 241.29 | |
| Formula: | C15H15NO2 | |
| Purity : | >98% | |
| Solubility: | DMSO : ≥ 100 mg/mL;H<sub>2</sub>O : < 0.1 mg/mL (ultrasonic) | |
| Mechanisms: | Target: Cancer Infection Inflammation/Immunology Neurological Disease | |
| Biological Activity: | ||
| Mefenamic acid is a BBB-permeable and non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively. IC50 & Target:IC50: 40 nM (hCOX-1), 3 μM (hCOX-2)[1] In Vitro:Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[1]. Mefenamic acid (0-100 μM) has cytotoxic effects on KB, Saos-2, and 1321N cells, however, U-87MG cells are resistant to Mefenamic acid[2]. | ||
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