Network Version
Zalcitabine Data Sheet
| Product Name: | Zalcitabine |
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|---|---|---|
| CAS No.: | 7481-89-2 | |
| Cat. No.: | HY-17392 | |
| MWt: | 211.221 | |
| Formula: | C9H13N3O3 | |
| Purity : | >98% | |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic);H<sub>2</sub>O : ≥ 25 mg/mL | |
| Mechanisms: | Target: Infection | |
| Biological Activity: | ||
| Zalcitabine is a potent nucleoside analogue reverse transcriptase inhibitor used in the treatment of HIV infection. IC50 & Target:Target: HIV In Vitro: Zalcitabine is a dideoxynucleoside antiretroviral agent that is phosphorylated to the active metabolite 2',3'-dideoxycytidine 5'-triphosphate (ddCTP) within both uninfected and HIV-infected cells. At therapeutic concentrations, ddCTP inhibits HIV replication by inhibiting the enzyme reverse transcriptase and terminating elongation of the proviral DNA chain[1]. Zalcitabine exhibits the inhibition effect on the cellular uptake of [3H]-PAH in CHO/hOAT1 cells with an IC50 value of 1.23 mM. Furthermore, the cellular uptake of zalcitabine increased threefold with the enhancement of hOATI activity in CHO/hOAT1 cells[2]. | ||
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