2-Hydroxyestradiol

Name: 2-Hydroxyestradiol
Brand: MedChemExpress
SKU: HY-124489
Rating: 4.5 (1 reviews)

Cat. No.: HY-124489 Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity.

For research use only. We do not sell to patients.

2-Hydroxyestradiol Chemical Structure

CAS No. : 362-05-0

Size	Price	Stock	Quantity
1 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 390	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 780	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1250	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2000	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 2-Hydroxyestradiol:

2-Hydroxyestradiol-d₅ In-stock
2-Hydroxyestradiol-¹³C₆ Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity^[1]^[3].

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

2-Hydroxyestradiol induces phenotypical changes indicative of neoplastic transformation^[1].
2-Hydroxyestradiol (2-OHE₂) is capable of in vitro transforming a HBEC, MCF-10F cell line, that is estrogen receptor-a (ERα) negative and ERβ positive^[1].
2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

2-Hydroxyestradiol attenuated the development of obesity and improved endothelial function, decreased nephropathy, decreased the severity of diabetes, lowered arterial blood pressure, and reduced plasma cholesterol^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

288.38

Formula

C₁₈H₂₄O₃

CAS No.

362-05-0

Appearance

Solid

Color

White to light yellow

SMILES

OC1=C(C=C(C2=C1)CC[C@@]3([C@@]2(CC[C@]4([C@]3(CC[C@@H]4O)[H])C)[H])[H])O

Structure Classification

Steroids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (346.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4676 mL	17.3382 mL	34.6765 mL
5 mM	0.6935 mL	3.4676 mL	6.9353 mL
10 mM	0.3468 mL	1.7338 mL	3.4676 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (275 KB) SDS (418 KB)

COA (252 KB) HNMR (260 KB) LCMS (260 KB)

Handling Instructions (2659 KB)

References

[1]. C H Van Aswegen, et al. Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. J Steroid Biochem. 1989 Apr;32(4):485-92. [Content Brief]

[2]. S P Tofovic, et al. 2-Hydroxyestradiol attenuates the development of obesity, the metabolic syndrome, and vascular and renal dysfunction in obese ZSF1 rats. J Pharmacol Exp Ther. 2001 Dec;299(3):973-7. [Content Brief]

[3]. Yeon-Jin Hurh, et al. 2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells. J Toxicol Environ Health A. 2004 Dec;67(23-24):1939-53. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4676 mL	17.3382 mL	34.6765 mL	86.6912 mL
	5 mM	0.6935 mL	3.4676 mL	6.9353 mL	17.3382 mL
	10 mM	0.3468 mL	1.7338 mL	3.4676 mL	8.6691 mL
	15 mM	0.2312 mL	1.1559 mL	2.3118 mL	5.7794 mL
	20 mM	0.1734 mL	0.8669 mL	1.7338 mL	4.3346 mL
	25 mM	0.1387 mL	0.6935 mL	1.3871 mL	3.4676 mL
	30 mM	0.1156 mL	0.5779 mL	1.1559 mL	2.8897 mL
	40 mM	0.0867 mL	0.4335 mL	0.8669 mL	2.1673 mL
	50 mM	0.0694 mL	0.3468 mL	0.6935 mL	1.7338 mL
	60 mM	0.0578 mL	0.2890 mL	0.5779 mL	1.4449 mL
	80 mM	0.0433 mL	0.2167 mL	0.4335 mL	1.0836 mL
	100 mM	0.0347 mL	0.1734 mL	0.3468 mL	0.8669 mL