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The Notch receptors are evolutionarily highly conserved single-pass transmembrane proteins that normally communicate signals upon binding to transmembrane ligands expressed on adjacent cells. The Notch family includes 4 receptors, NOTCH1, NOTCH2, NOTCH3, and NOTCH4, whose ligands include JAG1, JAG2, DLL1, DLL3, and DLL4. All of Notch receptors have an extracellular domain containing multiple epidermal growth factor (EGF)-like repeats and an intracellular region containing the RAM domain, ankyrin repeats, and a C-terminal PEST domain. Notch receptors function in highly conserved intercellular signaling pathway, which is highly conserved from Drosophila to humans, and play an important role in the regulation of cellular proliferation, differentiation and apoptosis. Constitutive activation of Notch signaling has been shown to result in excessive cellular proliferation and a wide range of malignancies, including leukemia, glioblastoma and lung and breast cancers.
The DLL4 protein, a homolog of the Drosophila delta gene family, encodes Notch ligands with a DSL domain, EGF repeats, and a transmembrane domain. DLL4 is widely expressed in tissues, including placenta (RPKM 11.5), fat (RPKM 11.2), and 22 others. Delta-like protein 4/DLL4 Protein, Human (HEK293, Fc) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Human (HEK293, Fc) is 498 a.a., with molecular weight of 100-110 kDa.
rHuDelta-like protein 4/DLL4, His; Delta-like protein 4; Drosophila Delta homolog 4; Delta4; DLL4
Human
HEK293
Delta-like protein 4 (DLL4) functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It regulates angiogenesis by inhibiting endothelial cell proliferation, migration, and angiogenesis. Delta-like protein 4/DLL4 Protein, Human (498a.a, HEK293, His) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Human (498a.a, HEK293, His) is 498 a.a., with molecular weight of 55-70 kDa.
Delta-like 4/DLL4 protein is a key player in the Notch signaling pathway, acting as a ligand to activate NOTCH1 and NOTCH4. In angiogenesis, DLL4 regulates endothelial cell proliferation, migration, and angiogenic sprouting. Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His) is 525 a.a., with molecular weight of ~68 kDa.
Delta-like protein 4 (DLL4) functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It regulates angiogenesis by inhibiting endothelial cell proliferation, migration, and angiogenesis. Delta-like protein 4/DLL4 Protein, Human (HEK293) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with tag free. The total length of Delta-like protein 4/DLL4 Protein, Human (HEK293) is 498 a.a., with molecular weight of 55-70 kDa.
Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Delta-like protein 3/DLL3 protein, expressed by HEK293 , with N-His labeled tag. The total length of Delta-like protein 3/DLL3 Protein, Human (Biotinylated, HEK293, His) is 464 a.a., with molecular weight of 52-60 kDa.
Delta-like protein 4 (DLL4) functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It regulates angiogenesis by inhibiting endothelial cell proliferation, migration, and angiogenesis. Delta-like protein 4/DLL4 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Human (Biotinylated, HEK293, His) is 498 a.a., with molecular weight of 60-70 kDa.
Jagged-1/JAG1 protein is a ligand for multiple Notch receptors and crucially mediates Notch signaling through interactions with NOTCH1, NOTCH2, and NOTCH3. Its role in hematopoiesis suggests its involvement in the regulation of blood cell development. Jagged-1/JAG1 Protein, Human (HEK293, His) is the recombinant human-derived Jagged-1/JAG1 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Jagged-1/JAG1 Protein, Human (HEK293, His) is 1013 a.a., with molecular weight of 150 kDa.
rHuDelta-like protein 1/DLL1, His; Delta-like protein 1; Drosophila Delta homolog 1; Delta1; H-Delta-1; DLL1
Human
HEK293
DLL1 protein is a transmembrane ligand for NOTCH1, NOTCH2 and NOTCH3 receptors and participates in cis- and trans-interactions. Trans interactions trigger mechanical forces involving clathrin-mediated endocytosis, ligand ubiquitination, EPN1 interactions, and actin polymerization. Delta-like protein 1/DLL1 Protein, Human (HEK293, His) is the recombinant human-derived Delta-like protein 1/DLL1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Delta-like protein 1/DLL1 Protein, Human (HEK293, His) is 523 a.a., with molecular weight of ~65.0 kDa.
Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (HEK293, His) is the recombinant human-derived Delta-like protein 3/DLL3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Delta-like protein 3/DLL3 Protein, Human (HEK293, His) is 466 a.a., with molecular weight of 53 kDa.
rHuJagged-1/JAG1, Fc; Protein jagged-1 I; Jagged-1; JAGL1; HJ1; JAG1 and CD339
Human
HEK293
Jagged-1/JAG1 protein is a ligand for multiple Notch receptors and crucially mediates Notch signaling through interactions with NOTCH1, NOTCH2, and NOTCH3. Its role in hematopoiesis suggests its involvement in the regulation of blood cell development. Jagged-1/JAG1 Protein, Human (HEK293, Fc) is the recombinant human-derived Jagged-1/JAG1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Jagged-1/JAG1 Protein, Human (HEK293, Fc) is 1013 a.a., with molecular weight of 140-200 kDa.
NOTCH2 protein is a receptor for ligands such as JAG1, JAG2 and DLL1 and is critical for cell fate determination. Ligand activation promotes cleavage and releases NICD, which forms a transcription activator complex with RBPJ/RBPSUH, affecting cell differentiation, proliferation and apoptosis. NOTCH2 Protein, Human (HEK293, His) is the recombinant human-derived NOTCH2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of NOTCH2 Protein, Human (HEK293, His) is 505 a.a., with molecular weight of 60-70 kDa.
Neurogenic locus notch homolog protein 1; Notch 1; Motch A; mT14
Human
HEK293
NOTCH1 protein is a receptor for the ligands JAG1, JAG2 and DLL1 and is critical for cell fate decisions. Upon ligand activation, NICD forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes in the cleavage site enhancer. NOTCH1 Protein, Human (HEK293, Fc) is the recombinant human-derived NOTCH1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of NOTCH1 Protein, Human (HEK293, Fc) is 508 a.a., with molecular weight of ~79.7 kDa.
delta-like protein 4 involves in the Notch signaling pathway as Notch ligand, and activates NOTCH1 and NOTCH4. delta-like protein 4 involves in angiogenesis. Delta-like protein 4/DLL4 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Rhesus Macaque (HEK293, His) is 502 a.a., with molecular weight of ~56.1 KDa.
Notch 3 protein is a receptor for the ligands JAG1, JAG2 and DLL1 and plays a crucial regulatory role in cell fate determination. Upon ligand activation, NICD forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes within the enhancer of the cleavage site. Notch3 Protein, Human (HEK293, Fc) is the recombinant human-derived Notch3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Notch3 Protein, Human (HEK293, Fc) is 428 a.a., with molecular weight of 75-83 kDa.
NOTCH1 protein is a receptor for the ligands JAG1, JAG2 and DLL1 and is critical for cell fate decisions. Upon ligand activation, NICD forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes in the cleavage site enhancer. NOTCH1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived NOTCH1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of NOTCH1 Protein, Human (HEK293, His-Avi) is 508 a.a., with molecular weight of 70-80 kDa.
Jagged-1/JAG1 protein is a multifunctional ligand that binds to multiple Notch receptors and mediates Notch signaling. It influences cell fate decisions during hematopoiesis, spans early and late mammalian cardiovascular development, and regulates myoblast differentiation. Jagged-1/JAG1 Protein, Mouse (Myc, His-SUMO) is the recombinant mouse-derived Jagged-1/JAG1 protein, expressed by E. coli , with C-Myc, N-SUMO, N-10*His labeled tag. The total length of Jagged-1/JAG1 Protein, Mouse (Myc, His-SUMO) is 302 a.a., with molecular weight of ~53.6 kDa.
Delta Drosophila like 3; Delta like 3 Drosophila; Delta like 3 homolog Drosophila; Delta like 3 protein; Delta like protein 3 precursor; SCDO1; SCOD1
Human
P. pastoris
Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (P.pastoris, His) is the recombinant human-derived Delta-like protein 3/DLL3 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Delta-like protein 3/DLL3 Protein, Human (P.pastoris, His) is 466 a.a., with molecular weight of ~56 kDa.
Notch homolog 2 N-terminal-like protein A; NOTCH2NLA; N2N
Human
HEK293
NOTCH2NL is a human-specific protein that promotes neural progenitor cell proliferation through Notch signaling regulation, thereby crucially driving the evolutionary expansion of the neocortex. By enhancing self-renewal and downregulating neuronal differentiation genes, NOTCH2NL delays progenitor cell maturation and promotes increased neuronal production. NOTCH2NL Protein, Human (HEK293, Fc) is the recombinant human-derived NOTCH2NL protein, expressed by HEK293 , with N-mFc labeled tag. The total length of NOTCH2NL Protein, Human (HEK293, Fc) is 236 a.a., with molecular weight of 55-75 KDa.
Delta-like protein 3 (DLL3) inhibits primary neurogenesis and directs neurons towards specific differentiation pathways. It also contributes to the formation of somite boundaries in the paraxial mesoderm segmentation. DLL3's importance in developmental processes is highlighted by its ability to bind and activate Notch-1 or other Notch receptors. Delta-like protein 3/DLL3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Delta-like protein 3/DLL3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Delta-like protein 3/DLL3 Protein, Mouse (HEK293, His) is 464 a.a., with molecular weight of 52-60 kDa.
Notch 3 protein is a receptor for the ligands JAG1, JAG2 and DLL1 and plays a crucial regulatory role in cell fate determination. Upon ligand activation, NICD forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes within the enhancer of the cleavage site. Notch 3 Protein, Human (HEK293, C-His-Avi) is the recombinant human-derived Notch 3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Notch 3 Protein, Human (HEK293, C-His-Avi) is 263 a.a., with molecular weight of 27-30 kDa & 10-12 kDa, respectively.