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Angiopoietins are a family of vascular growth factors that bind to TIE (Tyr kinase with Ig and epidermal growth factor homology domains) receptors. The growth factors ANG1, ANG2 and ANG4 (the human orthologue of mouse ANG3) are ligands for TIE2, whereas TIE1 remains an orphan receptor which is able to heterodimerize with TIE2 and to modulate TIE2 signal transduction. The Ang/Tie pathway plays an important role in the regulation of vascular stability, in angiogenesis under physiological and pathological conditions, as well as in inflammation. Under physiological conditions, ANG1 binds to and phosphorylates the TIE2 receptor, leading to downstream signalling that promotes cell survival and vascular stability. ANG2 is upregulated under pathological conditions and acts as a context-dependent agonist/antagonist of the Ang-1/Tie2 axis, causing vascular destabilisation and sensitising blood vessels to the effects of vascular endothelial growth factor-A (VEGF-A).
Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. Angiopoietin-2 Protein, Human (CHO, His) is the recombinant human-derived Angiopoietin-2 protein, expressed by CHO , with C-6*His labeled tag. The total length of Angiopoietin-2 Protein, Human (CHO, His) is 478 a.a., with molecular weight of ~62.6 kDa.
Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. Angiopoietin-2 Protein, Human (HEK293, His) is the recombinant human-derived Angiopoietin-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Angiopoietin-2 Protein, Human (HEK293, His) is 478 a.a., with molecular weight of ~63.5 kDa.
Angiopoietin 2 protein (ANGPT2) binds to TEK/TIE2, competes with ANGPT1, and modulates its signaling. Even in the absence of ANGPT1, ANGPT2 induces TEK/TIE2 phosphorylation. Angiopoietin-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Angiopoietin-2 protein, expressed by HEK293 , with N-His labeled tag. The total length of Angiopoietin-2 Protein, Mouse (HEK293, His) is 222 a.a., with molecular weight of ~33.4 kDa.
ANGPTL3; ANGPT5; ANG-5; Angiopoietin-5; FHBL2; ANL3; Angiopoietin-5; Angiopoietin-like Protein 3
Human
HEK293
ANGPTL3/Angiopoietin-like 3 protein, a hepatokine, intricately regulates lipid and glucose metabolism. It stimulates plasma triglycerides by inhibiting lipoprotein lipase (LPL), suppressing TG clearance through PCSK6 and FURIN recruitment, independent of proteolytic cleavage and unaffected by GPIHBP1. ANGPTL3 inhibits endothelial lipase, elevating HDL cholesterol, and activates adipocyte lipolysis. It selectively suppresses LPL in oxidative tissues, directing VLDL-TG to white adipose tissue, potentially cooperating with ANGPTL8 and ANGPTL4. ANGPTL3 also lowers LDL cholesterol independently of the canonical APOE and LDLR pathway, and may stimulate hypothalamic LPL activity. ANGPTL3/Angiopoietin-like 3 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived ANGPTL3/Angiopoietin-like 3 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of ANGPTL3/Angiopoietin-like 3 Protein, Human (Biotinylated, HEK293, His-Avi) is 203 a.a., with molecular weight of 30-38 kDa.
Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulating ANGPT1 signaling and inducing TEK/TIE2 phosphorylation even without ANGPT1. In the absence of angiogenic stimuli, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vascular regression. However, in the presence of VEGF, ANGPT2 collaborates to promote endothelial cell migration and proliferation, serving as a permissive angiogenic signal. Additionally, ANGPT2 regulates lymphangiogenesis, interacting with TEK/TIE2 and ITGA5, highlighting its diverse roles in angiogenesis and vascular control. Angiopoietin-2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Angiopoietin-2 protein, expressed by HEK293, with N-His, N-Avi labeled tag. The total length of Angiopoietin-2 Protein, Human (Biotinylated, HEK293, His-Avi) is 222 a.a., with molecular weight of 32-37 kDa.
Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. Angiopoietin-2 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Angiopoietin-2 protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of Angiopoietin-2 Protein, Human (HEK293, His-Avi) is 222 a.a., with molecular weight of 30-40 kDa.
TIE-1, a transmembrane kinase, modulates TEK/TIE2 activity, actively participating in the intricate regulation of angiogenesis. TIE-1 Protein, Human (HEK293, His) is the recombinant human-derived TIE-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TIE-1 Protein, Human (HEK293, His) is 739 a.a., with molecular weight of ~90.0 kDa.
TIE-2 protein has growth factor binding activity and is involved in ossification, cAMP response, and estrogen response. It is predicted to be present in a variety of cellular components, as a component of the plasma membrane, and as part of receptor complexes. TIE-2 Protein, Rat (HEK293, Fc) is the recombinant rat-derived TIE-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TIE-2 Protein, Rat (HEK293, Fc) is 721 a.a., with molecular weight of 120-130 kDa.
TIE-2 Protein, Mouse (HEK293, His) belongs to the receptor tyrosine kinase family and functions as a receptor for Angiopoietin-1 (Ang1). Ang1 bridges TIE-2 at cell-cell contacts, resulting in trans-association of TIE-2 in the presence of cell-cell contacts. TIE-2 activation promotes vessel assembly and maturation by mediating survival signals for EC and regulating the recruitment of pericytes. TIE-2 maintains the vascular integrity of mature vessels by enhancing endothelial barrier function and inhibiting apoptosis of endothelial cells. TIE-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TIE-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of TIE-2 Protein, Mouse (HEK293, His) is 722 a.a., with molecular weight of 95-120 kDa.
ANGPTL2/angiopoietin-like 2 protein takes center stage as it induces endothelial cell sprouting through dual autocrine and paracrine mechanisms. This ability underscores its critical role in angiogenesis, where balanced signaling events control the formation of new blood vessels. ANGPTL2/Angiopoietin-like 2 Protein, Human (HEK293, His-Avi) is the recombinant human-derived ANGPTL2/Angiopoietin-like 2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of ANGPTL2/Angiopoietin-like 2 Protein, Human (HEK293, His-Avi) is 234 a.a., with molecular weight of 31-35 kDa.
Angiopoietin-1 Protein, Human (HEK 293, Fc) is a recombinant Angiopoietin-1 protein with a Fc-flag. Angiopoietin-1 Protein is a secretory ligand of tyrosine kinase that is mainly expressed by vascular endothelial cells and hematopoietic cells. Angiopoietin-1 (Ang1) is a potential growth factor for therapeutic angiogenesis and vascular stabilization.
Angiopoietin 2 protein (ANGPT2) binds to TEK/TIE2, competes with ANGPT1, and modulates its signaling. Even in the absence of ANGPT1, ANGPT2 induces TEK/TIE2 phosphorylation. Angiopoietin-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Angiopoietin-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Angiopoietin-2 Protein, Mouse (HEK293, Fc) is 478 a.a., with molecular weight of 90-120 kDa.
ANGPT2/Angiopoietin-2 (dog) complexly regulates angiogenesis by binding to TEK/TIE2, competitively affecting ANGPT1 signaling. It independently induces TEK/TIE2 phosphorylation and, in the absence of VEGF, may cause endothelial cell apoptosis, thereby promoting vascular regression. Angiopoietin-2 Protein, Canine (HEK293, His) is the recombinant canine-derived Angiopoietin-2 protein, expressed by HEK293 , with N-His labeled tag. The total length of Angiopoietin-2 Protein, Canine (HEK293, His) is 222 a.a., with molecular weight of ~27.8 kDa.
TIE-2 belongs to the RTPK family of proteins and is a type I transmembrane protein. TIE-2 can serve as a receptor for growth factors, differentiation factors, and metabolic response stimulators. TIE-2 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived TIE-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TIE-2 Protein, Cynomolgus (HEK293, Fc) is 723 a.a., with molecular weight of ~130 kDa.
rMuAngiopoietin-Related Protein 4, C-Fc; ANGPTL4; Angiopoietin-Related Protein 4
Mouse
HEK293
Angiopoietin-related protein 4/ANGPTL4 Protein, Mouse (HEK293, Fc) expresses in HEK293 with an Fc fragment at the C-terminus. Angiopoietin-Related Protein 4 (ANGPTL4) is a multifunctional cytokine regulating vascular permeability, angiogenesis, and inflammation.
rHuAngiopoietin-Related Protein 4, His; ANGPTL4; Angiopoietin-Related Protein 4
Human
HEK293
Angiopoietin-like protein 4, Human modulates the disposition of circulating triglycerides (TG) by inhibiting lipoprotein lipase (LPL). Angiopoietin-Related Protein 4 is a conventional, non-competitive inhibitor that binds to LPL to prevent the hydrolysis of substrate as part of reversible mechanism.
Angiopoietin-2 Protein, Human (222a.a, HEK293, His) is a circulating antagonistic ligand of the endothelial-specific Tie2 receptor and has been identified as an important gatekeeper of endothelial activation.
rHuAngiopoietin-like Protein 8, N-Fc; ANGPTL8; Betatrophin; C19orf81; Angiopoietin-like Protein 8
Human
HEK293
ANGPTL 8 Protein, Human (HEK293, Fc) is a secreted inhibitor of LPL. Angiopoietin-like Protein 8 may function as an important metabolic switch, by forming complexes with ANGPTL3, or with ANGPTL4, in order to direct the flow of energy from triglycerides in blood according to the needs of the body.
rHuAngiopoietin-like Protein 3, His; ANGPTL3; Angiopoietin-like Protein 3
Human
HEK293
ANGPTL3/Angiopoietin-like 3 Protein, Human (204a.a, HEK293, His) plays an important role in lipoprotein metabolism. Angiopoietin-like Protein 3 acts as a dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL). Angiopoietin-like Protein 3 inhibits endothelial lipase hydrolysis of HDL-phospholipid (PL), thereby increasing HDL-PL levels.
ANGPT2 is a secreted factor on the angiopoietin/Tie (tyrosine kinase with Ig and EGF homology domains) signaling pathway and is involved in tumor angiogenesis. In the presence of ANGPT1, ANGPT2 antagonizes ANGPT1-mediated Tie2 phosphorylation, leading to vessel sprouting or degeneration depending on the level of VEGF-A. Overexpression or inhibition of ANGPT2 increases or decreases angiogenic capacity, respectively. Angiopoietin-2 Protein, Rhesus macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived Angiopoietin-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Angiopoietin-2 Protein, Rhesus macaque (HEK293, Fc) is 477 a.a., with molecular weight of 90-120 kDa.
