4-Methylhistamine dihydrochloride

Cat. No.: HY-107560 Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

4-Methylhistamine (dihydrochloride) is the potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine (dihydrochloride) has the potential for the research of immune-related diseases such as cancer and autoimmune disorders.

For research use only. We do not sell to patients.

4-Methylhistamine dihydrochloride Chemical Structure

CAS No. : 36376-47-3

Size	Price	Stock	Quantity
5 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 4-Methylhistamine dihydrochloride:

4-Methylhistamine Get quote
4-Methylhistamine hydrochloride Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

H₄ receptor

Molecular Weight

198.09

Formula

C₆H₁₃Cl₂N₃

CAS No.

36376-47-3

Appearance

Solid

Color

Off-white to light brown

SMILES

[H]Cl.CC1=C(CCN)NC=N1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (100.96 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 5 mg/mL (25.24 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.0482 mL	25.2411 mL	50.4821 mL
5 mM	1.0096 mL	5.0482 mL	10.0964 mL
10 mM	0.5048 mL	2.5241 mL	5.0482 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (251 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)

References

[1]. Ahmad SF, et al. Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance. Immunobiology. 2015;220(3):341-349. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	5.0482 mL	25.2411 mL	50.4821 mL	126.2053 mL
	5 mM	1.0096 mL	5.0482 mL	10.0964 mL	25.2411 mL
	10 mM	0.5048 mL	2.5241 mL	5.0482 mL	12.6205 mL
	15 mM	0.3365 mL	1.6827 mL	3.3655 mL	8.4137 mL
	20 mM	0.2524 mL	1.2621 mL	2.5241 mL	6.3103 mL
	25 mM	0.2019 mL	1.0096 mL	2.0193 mL	5.0482 mL
DMSO	30 mM	0.1683 mL	0.8414 mL	1.6827 mL	4.2068 mL
	40 mM	0.1262 mL	0.6310 mL	1.2621 mL	3.1551 mL
	50 mM	0.1010 mL	0.5048 mL	1.0096 mL	2.5241 mL
	60 mM	0.0841 mL	0.4207 mL	0.8414 mL	2.1034 mL
	80 mM	0.0631 mL	0.3155 mL	0.6310 mL	1.5776 mL
	100 mM	0.0505 mL	0.2524 mL	0.5048 mL	1.2621 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.