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  4. Boraginaceae

Boraginaceae

 

Boraginaceae (35):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0822
    Shikonin 517-89-5 99.80%
    Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.
    Shikonin
  • HY-N2181
    Acetylshikonin 24502-78-1 99.39%
    Acetylshikonin is an oral active anti-cancer, anti-inflammatory, antioxidant, anti-fertility, antibacterial, and neuroprotective agent. Acetylshikonin is a inhibitor of acetylcholinase (AChE) (IC50=34.6 μM) and nonselective cytochrome P450. Acetylshikonin can induce Apoptosis and Autophagy in cancer cells. Acetylshikonin regulates blood glucose, liver fat metabolism, and renal fibrosis, and is used in the study of diabetes, diabetic nephropathy (DN), obesity, and nonalcoholic fatty liver disease (NAFLD).
    Acetylshikonin
  • HY-N6012
    (-)-Alkannin 517-88-4 99.58%
    (-)-Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-)-Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-)-Alkannin improves hepatic inflammation in a Rho-kinase pathway.
    (-)-Alkannin
  • HY-N2187
    Deoxyshikonin 43043-74-9 99.96%
    Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF. Deoxyshikonin inhibited colorectal cancer (CRC) through the PI3K/Akt/mTOR pathway. Deoxyshikonin has proangiogenesis effect and antitumor activity. Deoxyshikonin is an antibacterial agent against methicillin-resistant S. aureus (MRSA) and S. pneumonia (MIC=17 μg/mL).
    Deoxyshikonin
  • HY-N5112B
    β,β-Dimethylacrylshikonin 24502-79-2 99.64%
    β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative isolated from Lithospermum erythrorhizon Sieb. et Zucc. , promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway.β,β-Dimethylacrylshikonin has anti-tumor activity.
    β,β-Dimethylacrylshikonin
  • HY-113845R
    (+)-Intermedine (Standard) 10285-06-0
    (+)-Intermedine (Standard) is the analytical standard of (+)-Intermedine. This product is intended for research and analytical applications. (+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs).
    (+)-Intermedine (Standard)
  • HY-N3036
    (Rac)-Isovalerylshikonin 76549-35-4
    (Rac)-Isovalerylshikonin (compound 372) is a naphthoquinone pigment present in hexane extracts of safflower roots.
    (Rac)-Isovalerylshikonin
  • HY-N12747
    Dichlorogelignate 164030-91-5
    Dichlorogelignate (compound 4) is a selective inhibitor of topoisomerase II (Topo II). Dichlorogelignate has 100% inhibition at 50 μM.
    Dichlorogelignate
  • HY-N7610
    Acetylalkannin 34232-27-4 99.85%
    Acetylalkannin (Alkannin acetate) is an isohexenylnaphthazarin pigment isolated from Arnebia euchroma with antimicrobial and cytotoxic activities.
    Acetylalkannin
  • HY-113845
    (+)-Intermedine 10285-06-0 ≥99.0%
    (+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs).
    (+)-Intermedine
  • HY-N2188
    Beta-Acetoxyisovalerylshikonin 69091-17-4 99.62%
    Beta-Acetoxyisovalerylshikonin is a naphthoquinone derivative isolated from Arnebia euchroma.
    Beta-Acetoxyisovalerylshikonin
  • HY-N4201
    β-Hydroxyisovalerylshikonin 7415-78-3 99.83%
    Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells.
    β-Hydroxyisovalerylshikonin
  • HY-N2592
    Isobutylshikonin 52438-12-7 99.53%
    Isobutylshikonin is a kind of shikonin pigments from hairy root culture of Lithospermum canescens.
    Isobutylshikonin
  • HY-N5112
    (Rac)-Arnebin 1 5162-01-6 99.36%
    (Rac)-Arnebin 1 ((Rac)-β,β-Dimethylacrylalkannin) is the racemate of β,β-Dimethylacrylalkannin and/or β,β-Dimethylacrylshikonin. β,β-Dimethylacrylalkannin and β,β-Dimethylacrylshikonin are napthoquinones isolated from Arnebia nobilis. β,β-Dimethylacrylshikonin has anti-tumor activity.
    (Rac)-Arnebin 1
  • HY-N11891
    4-(β-D-glucopyranosyloxy)benzoic acid 15397-25-8
    4-(β-D-glucopyranosyloxy)benzoic acid is a phenolic glucoside can be isolated from fennel seeds.
    4-(β-D-glucopyranosyloxy)benzoic acid
  • HY-105529
    Indicine N-oxide 41708-76-3
    Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an antitumor agent for pediatric cancer and solid tumors research.
    Indicine N-oxide
  • HY-121286
    Echinatine 480-83-1
    Echinatine is an active compound. Echinatine can be derived from C. barrelieri. C. barrelieri exhibits strong antioxidant activity.
    Echinatine
  • HY-121390
    Lasiocarpine 303-34-4
    Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide.
    Lasiocarpine
  • HY-122931
    Supinine 551-58-6
    Supinine is an alkaloid. Supinine can be isolated from Heliotropium europaeum.
    Supinine
  • HY-124140
    Heliosupine 32728-78-2
    Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC50 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores.
    Heliosupine