2. Signaling Pathways
  3. PROTAC
  4. E3 Ligase Ligand-Linker Conjugates
  5. Cereblon Isoform

Cereblon

 

Cereblon Related Products (221):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-14658
    Thalidomide 50-35-1 99.92%
    Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.
    Thalidomide
  • HY-41547
    Thalidomide 4-fluoride 835616-60-9 99.65%
    Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966).
    Thalidomide 4-fluoride
  • HY-23095
    Thalidomide-5-OH 64567-60-8 99.65%
    Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs.
    Thalidomide-5-OH
  • HY-W087383
    Thalidomide 5-fluoride 835616-61-0 99.9%
    Thalidomide 5-fluoride is Thalidomide-based cereblon ligand that incorporates to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
    Thalidomide 5-fluoride
  • HY-103596
    Thalidomide-4-OH 5054-59-1 99.85%
    Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs.
    Thalidomide-4-OH
  • HY-160241
    Lenalidomide-C5-acid 2338824-30-7
    Lenalidomide-C5-acid is the Lenalidomide-based E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Lenalidomide-C5-acid can be used to synthesize PROTACs.
    Lenalidomide-C5-acid
  • HY-W145436
    Thalidomide-Piperazine 5-fluoride hydrochloride 2222114-23-8
    Thalidomide-Piperazine 5-fluoride hydrochloride is a derivative of cereblon (CRBN) inhibitor Thalidomide (HY-14658), which can be used as ligands for E3 ubiquitin ligase (Ligands for E3 Ligase) for PROTACs Synthesis.
    Thalidomide-Piperazine 5-fluoride hydrochloride
  • HY-139332
    Pomalidomide 4'-PEG6-azide 2624181-62-8
    Pomalidomide 4'-PEG6-azide (compound 33e) is the E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC3-acid can be used to synthesize PROTACs.
    Pomalidomide 4'-PEG6-azide
  • HY-122725B
    Lenalidomide-C5-NH2 hydrochloride 2595367-27-2 98.44%
    Lenalidomide-C5-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader.
    Lenalidomide-C5-NH2 hydrochloride
  • HY-125843
    Pomalidomide-PEG1-C2-N3 2271036-44-1 99.91%
    Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM. Pomalidomide-PEG1-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Pomalidomide-PEG1-C2-N3
  • HY-141012
    Thalidomide-O-PEG4-NHS ester 2411681-88-2 98.23%
    Thalidomide-O-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thalidomide-O-PEG4-NHS ester
  • HY-103597
    Thalidomide-O-COOH 1061605-21-7 99.85%
    Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs.
    Thalidomide-O-COOH
  • HY-131647
    Pomalidomide 4'-PEG5-acid 2139348-63-1
    Pomalidomide 4'-PEG5-acid (Pomalidomide-PEG5-CO2H) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 5-unit PEG linker used in PROTAC technology.
    Pomalidomide 4'-PEG5-acid
  • HY-130737
    Pomalidomide 4'-alkylC5-acid 2225940-49-6 98.78%
    Pomalidomide 4'-alkylC5-acid (Example 3) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC5-acid can be used in the synthesis of PROTAC.
    Pomalidomide 4'-alkylC5-acid
  • HY-75706
    N-Descyclopropanecarbaldehyde Olaparib 763111-47-3 99.27%
    N-Descyclopropanecarbaldehyde Olaparib is an analogue of Olaparib containing DOTA moiety. N-Descyclopropanecarbaldehyde Olaparib is a CRBN-based ligand for synthesizing novel dual EGFR and PARP PROTAC, DP-C-4. N-Descyclopropanecarbaldehyde Olaparib can be radiolabeled F-18 or fluorophore for positron emission tomography (PET) or optical imaging in several types of tumor.
    N-Descyclopropanecarbaldehyde Olaparib
  • HY-128846A
    Pomalidomide-C2-NH2 hydrochloride 2305369-00-8 99.46%
    Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
    Pomalidomide-C2-NH2 hydrochloride
  • HY-131717
    Thalidomide-NH-CH2-COOH 927670-97-1 98.20%
    Thalidomide-NH-CH2-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-NH-CH2-COOH can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032 (HY-123937).
    Thalidomide-NH-CH2-COOH
  • HY-141015
    Pomalidomide-PEG4-azide 2271036-47-4 99.85%
    Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. Pomalidomide-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    Pomalidomide-PEG4-azide
  • HY-126458
    Thalidomide-O-PEG2-propargyl 2098487-52-4 98.26%
    Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. Thalidomide-O-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Thalidomide-O-PEG2-propargyl
  • HY-137531
    Pomalidomide-PEG1-C2-COOH 2139348-60-8 99.88%
    Pomalidomide-PEG1-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology.
    Pomalidomide-PEG1-C2-COOH