IRAK Inhibitors

IRAK1

IRAK4

IRAK Degraders, Inhibitors & Modulators

Product Name	IRAK1	IRAK4	Purity
Zimlovisertib		IRAK4, IC₅₀: 0.2 nM	99.71%
Ginsenoside Rb1	IRAK-1		98.75%
Emavusertib		IRAK4, IC₅₀: 57 nM	99.96%
KT-474		IRAK4	99.27%
JH-X-119-01 hydrochloride	IRAK1		98.15%
Emavusertib hydrochloride		IRAK4, IC₅₀: 57 nM
KME-2780	IRAK1	IRAK4
IRAK4 modulator-1		IRAK4, IC₅₀: 4.647 μM (^[1])
HS-276	IRAK1, IC₅₀: 264 nM	IRAK4, IC₅₀: 2500 nM	98.59%
Zabedosertib		IRAK4, IC₅₀: 3.55 nM	98.14%
JH-X-119-01	IRAK-1, IC₅₀: 9 nM		≥98.0%
PROTAC IRAK4 degrader-1		IRAK4	99.72%
AZ1495	IRAK1, IC₅₀: 23 nM	IRAK4, IC₅₀: 5 nM	98.18%
HS-243	IRAK-1, IC₅₀: 24 nM	IRAK4, IC₅₀: 20 nM	99.88%
AS2444697		IRAK4, IC₅₀: 21 nM	99.12%
JNJ-1013	IRAK1, IC₅₀: 72 nM	IRAK4, IC₅₀: 443 nM	99.80%
IRAK4-IN-7		IRAK4	99.36%
PF-06426779		IRAK4, IC₅₀: 0.3 nM	99.83%
PROTAC IRAK4 degrader-3		IRAK4
Larotinib mesylate hydrate	IRAK-1, IC₅₀: 167 nM		98.66%
GLPG2534	IRAK1, IC₅₀: 179 nM	hIRAK4, IC₅₀: 6.4 nM mIRAK4, IC₅₀: 3.5 nM	98.05%
IRAK-4 protein kinase inhibitor 2		IRAK4, IC₅₀: 4 μM	98.01%
IRAK inhibitor 4 (trans)		IRAK4	99.02%
HS271		IRAK4, IC₅₀: 7.2 μM	99.92%
IRAK4-IN-14		IRAK4, IC₅₀: 0.003 μM
Larotinib	IRAK1, IC₅₀: 167 nM
IRAK4-IN-8		IRAK4
IRAK4-IN-18		IRAK4, IC₅₀: 15 nM
PROTAC IRAK4 degrader-5		IRAK4
IRAK4-IN-16		IRAK4, IC₅₀: 2.5 ± 0.8 nM
IRAK4-IN-9		IRAK4, IC₅₀: 1.5 nM
IRAK4-IN-10		IRAK4, IC₅₀: 1.5 nM
IRAK4-IN-13		IRAK4, IC₅₀: 0.6 nM
DW18134		IRAK4, IC₅₀: 11.2 nM
KTX-612		IRAK4, DC₅₀: 7 nM
BIO-8169		IRAK4, IC₅₀: 0.23 nM
PROTAC IRAK4 degrader-4		IRAK4
BIO-7488		hIRAK4, IC₅₀: 0.6 nM
IRAK4-IN-20		IRAK4, IC₅₀: 3.55 nM
Ginsenoside Rb1 (Standard)	IRAK-1
KTX-497		IRAK4, DC₅₀: 3 nM
KTX-955		IRAK4, IC₅₀: 5 nM
IRAK4-IN-15		IRAK4, IC₅₀: 0.002 μM
IRAK4-IN-12		IRAK4, IC₅₀: 0.015 μM
IRAK4-IN-17		IRAK4, IC₅₀: 1.3 nM
PROTAC IRAK4 degrader-6		IRAK4
IRAK4-IN-11		IRAK4, IC₅₀: .008 μM
IRAK4-IN-19		IRAK4, IC₅₀: 4.3 nM
HG-12-6		IRAK4, IC₅₀: 165 nM (Unphosphorylated inactive IRAK4 ) IRAK4, IC₅₀: 2876 nM (Phosphorylated active IRAK4 )
GNE-2256		IRAK4, Ki: 1.4 nM
IRAK4-IN-24		IRAK4
IRAK4-IN-27		IRAK4, IC₅₀: 8.7 nM
PROTAC IRAK4 degrader-2		IRAK4

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