2. Neuronal Signaling
  3. Sigma Receptor
  4. AB21 hydrochloride

AB21 hydrochloride is a potent and selective S1R antagonist with Kis of 13, 102 nM for S1R and S2R. AB21 hydrochloride has the effect of reducing mechanical hypersensitivity.

For research use only. We do not sell to patients.

AB21 hydrochloride Chemical Structure

AB21 hydrochloride Chemical Structure

CAS No. : 3026677-24-4

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AB21 hydrochloride Related Antibodies

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Description

AB21 hydrochloride is a potent and selective S1R antagonist with Kis of 13, 102 nM for S1R and S2R. AB21 hydrochloride has the effect of reducing mechanical hypersensitivity[1].

In Vitro

AB21 hydrochloride shows Kis of 12 nM and 14 nM with or without Phenytoin in the S1R Radioligand Binding Assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AB21 hydrochloride Related Antibodies
In Vivo

AB21 hydrochloride (20 mg/kg, s.c., administered 30 min before the injection of Capsaicin (HY-10448)) reverses mechanical allodyniain in Capsaicin (HY-B0448)-induced pain model, and exhibits higher potency than BD1063 dhydrochloride (HY-18101A)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Capsaicin-induced mechanical hypersensitivity model in mice[1].
Dosage: 20 mg/kg
Administration: Subcutaneous injection (s.c.); administered 30 min before the injection of capsaicin.
Result: Result: Showed complete reversal of the mechanical hypersensitivity reaction and the dose administered was half that of BD-1063 (40 mg/kg).
Molecular Weight

384.94

Formula

C23H29ClN2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(CC1)CCC21CN(CCC3=CC=CC=C3)C2)CC4=CC=CC=C4.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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AB21 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AB213026677-24-4AB 21AB-21Sigma ReceptorS1R antagonistCapsaicin-induced mechanical hypersensitivityInhibitorinhibitorinhibit

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AB21 hydrochloride
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HY-149854B
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