2. Neuronal Signaling
  3. Cholinesterase (ChE) Amyloid-β
  4. AChE-IN-62

AChE-IN-62 (Compound 1) is an effective mixed and selective acetylcholinesterase (AChE) inhibitor with an IC50 value of 0.421 μM. AChE-IN-62 exhibits excellent blood-brain barrier permeability and neuroprotective effects. Additionally, AChE-IN-62 can inhibit the aggregation of Aβ1?42 with an IC50 value of 44.64 μM. AChE-IN-62 is also an effective multi-target-directed ligand (MTDL) that can be utilized in the research of Alzheimer's disease.

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AChE-IN-62 Chemical Structure

AChE-IN-62 Chemical Structure

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AChE-IN-62 Related Antibodies

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Description

AChE-IN-62 (Compound 1) is an effective mixed and selective acetylcholinesterase (AChE) inhibitor with an IC50 value of 0.421 μM. AChE-IN-62 exhibits excellent blood-brain barrier permeability and neuroprotective effects. Additionally, AChE-IN-62 can inhibit the aggregation of Aβ1?42 with an IC50 value of 44.64 μM. AChE-IN-62 is also an effective multi-target-directed ligand (MTDL) that can be utilized in the research of Alzheimer's disease[1].

IC50 & Target

IC50: 0.421 μM (AChE)[1].
In Vitro

AChE-IN-62 (50 μM; 24-48 h) effectively inhibits the aggregation of Aβ1−42 with an IC50 value of 44.64 μM[1].
AChE-IN-62 (5-20 μM; 24 h) demonstrates neuroprotective effects in SH-SY5Y and Neuro2A cells by ameliorating the neurotoxic effects mediated by H2O2 (200 μM; 24 h) and Okadaic acid (HY-N6785) (30 nM; 24 h)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AChE-IN-62 Related Antibodies

Cell Viability Assay[1]

Cell Line: SH-SY5Y, Neuro2A
Concentration: 5 μM, 10 μM, 20 μM;
Incubation Time: 24 h
Result: Inhibited the cell death mediated by H2O2 (200 μM; 24 h) and Okadaic acid (HY-N6785).
In Vivo

AChE-IN-62 (Compound 1) (10-20 mg/kg; i.p.; once daily for 7 days) improves the memory decline and learning disabilities induced by scopolamine (HY-N0296) (3 mg/kg; i.p.; once daily for 7 days) in Swiss albino mice with dementia by repairing the damage to the cortex and hippocampus, thus exerting a protective effect against the harm caused by scopolamine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Dementia model of Swiss albino mice mediated by scopolamine[1].
Dosage: 5 mg/kg, 10 mg/kg
Administration: Intraperitoneal injection (i.p.); Once daily for 7 days. Before scopolamine (HY-N0296) treatment (3 mg/kg; i.p.; Once daily for 7 days)
Result: Reduced the recognition ratio (T2/T1) in mice (a lower T2/T1 value indicates stronger short-term recognition memory).
Significantly enhanced the step-through latency (STL) (a decrease in STL indicates impaired memory).
Molecular Weight

431.53

Formula

C19H21N5O3S2
SMILES

CS(C1=CC=C2C(SC(NC(CN3CCN(C4=CC=CC=N4)CC3)=O)=N2)=C1)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AChE-IN-62 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-62Cholinesterase (ChE)Amyloid-ββ-amyloid peptideAβAbetaAlzheimer’s disease (AD)multi-target- directed ligand (MTDL)SH-SY5Ymulti-target- directed ligand (MTDL)Neuro2ABlood-Brain Barrier (BBB)neuroprotectionInhibitorinhibitorinhibit

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