Ambruticin  (Synonyms: W7783)

Ambruticin (W7783) is an orally active and potent antifungal antibiotic. Ambruticin represents a class of antibiotics, that can be isolated from a strain of Polyangium cellulosum var. fulvum, a bacterium belonging to the class Myxobacteriales. Ambruticin is a cyclopropyl-polyene-pyran acid and is active against fungi^[1].

Ambruticin is highly active against the yeast and filamentous phases of H. capsulatum and B. dermatitidis; the MIC range was 0.049 to 0.39 μg/mL, and the order of activity appeared similar to amphotericin B (HY-B0221)^[2].
Ambruticin MIC is 1.56 μg/mL and the Griseofulvin (HY-17583) MIC was 3.12 μg/mL against M.fulvum^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

The acute LD₅₀ values for the sodium salt of Ambruticin in mice were: intravenous 315 mg/kg, oral > 1000 mg/kg^[1].
Ambruticin is rapidly absorbed by the oral route in mice. Ambruticin (75 mg/kg, gavage) produces a peak serum level of 46 μg/mL with a serum half-life of 3.1 h^[2].
Ambruticin (40 mg/kg, oral, twice daily for a total of 10 days) shows protective activity in Guinea pigs infected with a severe T. mentagrophytes challenge^[2].
Ambruticin shows protective activity in mice acutely infected with a severe C. albicans challenge^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

474.63

C₂₈H₄₂O₆

58857-02-6

OC(C[C@H](C[C@@H]([C@H]1O)O)O[C@H]1/C=C/[C@@H]2[C@H]([C@H]2C)/C=C/[C@@H](C)/C=C([C@@H]3O[C@@H](C(C)=CC3)CC)\C)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ringel SM, et al. Ambruticin (W7783), a new antifungal antibiotic. J Antibiot (Tokyo). 1977 May;30(5):371-5.  [Content Brief]

  [2]. Ringel SM. In vitro and in vivo studies of ambruticin (W7783): new class of antifungal antibiotics. Antimicrob Agents Chemother. 1978 May;13(5):762-9.  [Content Brief]