2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 105

Anticancer agent 105 is a compound based on thienopyrimidine scaffold, with with good safety and anticancer properties. Anticancer agent 105 shows selective toxicity towards melanoma cancer, and induces apoptosis. And Anticancer agent 105 significantly inhibits the metastatic nodules, even in pulmonary metastatic melanoma mouse model.

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Anticancer agent 105 Chemical Structure

Anticancer agent 105 Chemical Structure

CAS No. : 2450987-57-0

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Description

Anticancer agent 105 is a compound based on thienopyrimidine scaffold, with with good safety and anticancer properties. Anticancer agent 105 shows selective toxicity towards melanoma cancer, and induces apoptosis. And Anticancer agent 105 significantly inhibits the metastatic nodules, even in pulmonary metastatic melanoma mouse model[1].

In Vitro

Anticancer agent 105 (compound 9cb) shows selectivity against cancer cells, while it inhibits survival of cancerous cells (B16–F10 melanoma) and normal non-cancerous fibroblasts (MEF NF2) with IC50s of 2.41 μM, and >100 μM, respectively[1].
Anticancer agent 105 (0.5-10 μM; 24 h) shows toxicity against cancer cells, and (5-20 μM; 48 h) induces apoptosis and necrosis in B16-F10 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 105 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: B16-F10 melanoma
Concentration: 0.5 μM, 1 μM, 5 μM, and 10 μM
Incubation Time: 24 h
Result: Exhibited very low toxicity or were non-toxic in the case of MEF NF2 cells in the range of concentration 0.2-55 μM.

Apoptosis Analysis[1]

Cell Line: B16-F10 melanoma
Concentration: 5 μM, 10 μM, 15 μM, and 20 μM
Incubation Time: 48 h
Result: Induced early apoptosis and resulted nuclear condensation.
In Vivo

Anticancer agent 105 (compound 9cb) (9-9.5 mg/kg every 3rd d for 22 d; ip) inhibits metastatic nodules in B16-F10 melanoma-bearing C57BL/6 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pulmonary metastatic melanoma mouse model[1]
Dosage: I: 9-9.5 mg/kg; II: 42-4.6 mg/kg
Administration: IP; once daily every 3rd d for 22 d
Result: Decreased the number of metastatic nodules in mouse.
Molecular Weight

533.64

Formula

C25H24KN3O6S
CAS No.
SMILES

O=C(OCC)C1=C(NC(/C(O[K])=C(C(N)=O)\C#N)=C\C(C2=CC=C(OC)C=C2)=O)SC3=C1CCCC3
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Anticancer agent 105 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 1052450987-57-0Anticancer agent105Anticancer agent-105Apoptosismetastatic nodulespulmonary metastatic melanoma mouse modelthienopyrimidine scaffoldgood safetyInhibitorinhibitorinhibit

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