2. PROTAC Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor PROTACs
  4. ARD-1676

ARD-1676 is an orally available androgen receptor (AR) PROTAC degrader, consisting of AR ligand and cereblon ligand. ARD-1676 has AR-degrading activity in vitro and in vivo and inhibits VCaP tumor growth in mouse xenograft tumor models.

For research use only. We do not sell to patients.

ARD-1676 Chemical Structure

ARD-1676 Chemical Structure

CAS No. : 2632305-36-1

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5 mg USD 850 In-stock
10 mg USD 1430 In-stock
25 mg USD 3000 In-stock
50 mg USD 4800 In-stock
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Based on 1 publication(s) in Google Scholar

ARD-1676 Related Antibodies

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Description

ARD-1676 is an orally available androgen receptor (AR) PROTAC degrader, consisting of AR ligand and cereblon ligand. ARD-1676 has AR-degrading activity in vitro and in vivo and inhibits VCaP tumor growth in mouse xenograft tumor models[1].

In Vitro

The DC50 values of ARD-1676 for AR degradation in AR+ VCaP and LNCaP cell lines are 0.1 and 1.1 nM, respectively, and the IC50 values in VCaP and LNCaP cell lines are 11.5 and 2.8 nM respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ARD-1676 Related Antibodies
In Vivo

The oral bioavailability of ARD-1676 was 67%, 44%, 31%, and 99% in mice, rats, dogs, and monkeys, respectively. ARD-1676 effectively reduces AR protein levels in mouse VCaP tumor tissues and inhibits tumor growth in VCaP mouse xenograft tumor models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

788.33

Formula

C44H46ClN7O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@H]1CC2(CN1C3=CC=C(C(Cl)=C3)C#N)CCN(CC2)C4=CC=C(C=C4)C(N5CCC(CC5)CN6CC7=C(C6)C=C8C(N(C(C8=C7)=O)C9CCC(NC9=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (126.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2685 mL 6.3425 mL 12.6850 mL
5 mM 0.2537 mL 1.2685 mL 2.5370 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2685 mL 6.3425 mL 12.6850 mL 31.7126 mL
5 mM 0.2537 mL 1.2685 mL 2.5370 mL 6.3425 mL
10 mM 0.1269 mL 0.6343 mL 1.2685 mL 3.1713 mL
15 mM 0.0846 mL 0.4228 mL 0.8457 mL 2.1142 mL
20 mM 0.0634 mL 0.3171 mL 0.6343 mL 1.5856 mL
25 mM 0.0507 mL 0.2537 mL 0.5074 mL 1.2685 mL
30 mM 0.0423 mL 0.2114 mL 0.4228 mL 1.0571 mL
40 mM 0.0317 mL 0.1586 mL 0.3171 mL 0.7928 mL
50 mM 0.0254 mL 0.1269 mL 0.2537 mL 0.6343 mL
60 mM 0.0211 mL 0.1057 mL 0.2114 mL 0.5285 mL
80 mM 0.0159 mL 0.0793 mL 0.1586 mL 0.3964 mL
100 mM 0.0127 mL 0.0634 mL 0.1269 mL 0.3171 mL
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ARD-1676 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARD-16762632305-36-1ARD1676ARD 1676Androgen ReceptorPROTACsandrogen receptorAR+ VCaP cellAR+ LNCaP cellInhibitorinhibitorinhibit

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