2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Asoxime dichloride

Asoxime dichloride  (Synonyms: HI-6)

Cat. No.: HY-106901A Purity: ≥98.0%
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Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride involves in modulating immunity response. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system.

For research use only. We do not sell to patients.

Asoxime dichloride Chemical Structure

Asoxime dichloride Chemical Structure

CAS No. : 34433-31-3

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5 mg USD 63 In-stock
10 mg USD 105 In-stock
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Based on 1 publication(s) in Google Scholar

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Asoxime dichloride Related Antibodies

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Description

Asoxime dichloride (HI-6) is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride involves in modulating immunity response. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system[1].

IC50 & Target

IC50: acetylcholine receptors (AChRs)[1]
In Vivo

Asoxime dichloride (intramuscular injection into the rear limb; 2% and 0.2% of median lethal dose 15.6 and 1.56 mg/kg; 21 or 65 days) significantly improved vaccination efficacy as a dose-dependent manner when KLH is 1 mg/kg. A combination of HI-6 and keyhole limpet hemocyanin (KLH) produces a vaccination of almost the same efficacy as that for Freund's complete adjuvant[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice[1]
Dosage: 2% and 0.2% of median lethal dose 15.6 and 1.56mg/kg
Administration: Intramuscular injection into the rear limb
Result: Improved vaccination efficacy at the level of immunity regulation by the nervous system.
Molecular Weight

359.21

Formula

C14H16Cl2N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O/N=C/C1=CC=CC=[N+]1COC[N+]2=CC=C(C(N)=O)C=C2.[Cl-].[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (278.39 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7839 mL 13.9194 mL 27.8389 mL
5 mM 0.5568 mL 2.7839 mL 5.5678 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.7839 mL 13.9194 mL 27.8389 mL 69.5972 mL
5 mM 0.5568 mL 2.7839 mL 5.5678 mL 13.9194 mL
10 mM 0.2784 mL 1.3919 mL 2.7839 mL 6.9597 mL
15 mM 0.1856 mL 0.9280 mL 1.8559 mL 4.6398 mL
20 mM 0.1392 mL 0.6960 mL 1.3919 mL 3.4799 mL
25 mM 0.1114 mL 0.5568 mL 1.1136 mL 2.7839 mL
30 mM 0.0928 mL 0.4640 mL 0.9280 mL 2.3199 mL
40 mM 0.0696 mL 0.3480 mL 0.6960 mL 1.7399 mL
50 mM 0.0557 mL 0.2784 mL 0.5568 mL 1.3919 mL
60 mM 0.0464 mL 0.2320 mL 0.4640 mL 1.1600 mL
80 mM 0.0348 mL 0.1740 mL 0.3480 mL 0.8700 mL
100 mM 0.0278 mL 0.1392 mL 0.2784 mL 0.6960 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Asoxime dichloride34433-31-3HI-6HI6HI 6nAChRNicotinic acetylcholine receptorsAChRnervousvaccinationantigenInhibitorinhibitorinhibit

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