2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. HPPE

HPPE (compound 236) is a potential Bach1 inhibitor. Bach1 is a transcription factor of the cap'n'collar type alkaline region leucine zipper factor family (CNC-bZip) that regulates mitochondrial metabolism and reduces glucose utilization. HPPE can be used for research in psoriasis, multiple sclerosis, and COPD.

For research use only. We do not sell to patients.

HPPE Chemical Structure

HPPE Chemical Structure

CAS No. : 1325721-55-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 148 In-stock
Solution
10 mM * 1 mL in DMSO USD 148 In-stock
Solid
5 mg USD 140 In-stock
10 mg USD 220 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

HPPE Related Antibodies

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Description

HPPE (compound 236) is a potential Bach1 inhibitor. Bach1 is a transcription factor of the cap'n'collar type alkaline region leucine zipper factor family (CNC-bZip) that regulates mitochondrial metabolism and reduces glucose utilization. HPPE can be used for research in psoriasis, multiple sclerosis, and COPD[1][2].

IC50 & Target

Bach1[1]
Molecular Weight

479.48

Formula

C21H20F3N5O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(N=C(N2C)NC3=NC4=C(S3)C=C(C(F)(F)F)C=C4)=C2C=C1)NCCOCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (260.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0856 mL 10.4280 mL 20.8559 mL
5 mM 0.4171 mL 2.0856 mL 4.1712 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.81%

COA (245 KB) HNMR (301 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0856 mL 10.4280 mL 20.8559 mL 52.1398 mL
5 mM 0.4171 mL 2.0856 mL 4.1712 mL 10.4280 mL
10 mM 0.2086 mL 1.0428 mL 2.0856 mL 5.2140 mL
15 mM 0.1390 mL 0.6952 mL 1.3904 mL 3.4760 mL
20 mM 0.1043 mL 0.5214 mL 1.0428 mL 2.6070 mL
25 mM 0.0834 mL 0.4171 mL 0.8342 mL 2.0856 mL
30 mM 0.0695 mL 0.3476 mL 0.6952 mL 1.7380 mL
40 mM 0.0521 mL 0.2607 mL 0.5214 mL 1.3035 mL
50 mM 0.0417 mL 0.2086 mL 0.4171 mL 1.0428 mL
60 mM 0.0348 mL 0.1738 mL 0.3476 mL 0.8690 mL
80 mM 0.0261 mL 0.1303 mL 0.2607 mL 0.6517 mL
100 mM 0.0209 mL 0.1043 mL 0.2086 mL 0.5214 mL
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HPPE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HPPE1325721-55-8Bach1-IN-1Mitochondrial MetabolismInhibitorinhibitorinhibit

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