Ras association domain-containing protein 2

Definition:

Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.

References:

[1]. W N Cooper, et al. RASSF2 associates with and stabilizes the proapoptotic kinase MST2. Oncogene. 2009 Aug 20;28(33):2988-98. [Content Brief]

[2]. Michele D Vos, et al. RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor. J Biol Chem. 2003 Jul 25;278(30):28045-51. [Content Brief]

[3]. Kimishige Akino, et al. The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. Gastroenterology. 2005 Jul;129(1):156-69. [Content Brief]

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