Telomerase protein component 1

Definition:

Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also a component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport (By similarity). Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity).

References:

[1]. Andrew S Venteicher, et al. A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. Science. 2009 Jan 30;323(5914):644-8. [Content Brief]

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