Terminal nucleotidyltransferase 5D

Definition:

Catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group.

References:

[1]. Hua Chen, et al. Structural and Functional Analyses of the FAM46C/Plk4 Complex. Structure. 2020 Aug 4;28(8):910-921.e4. [Content Brief]

[2]. Seweryn Mroczek, et al. The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma. Nat Commun. 2017 Sep 20;8(1):619. [Content Brief]

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