The Bromodomain and Extra-Terminal (BET) family of proteins

Definition:

The Bromodomain and Extra-Terminal (BET) family of proteins is characterized by the presence of two tandem bromodomains and an extra-terminal domain.The mammalian BET family of proteins comprises BRD2, BRD3, BRD4, and BRDT, which are encoded by paralogous genes.BET proteins play a crucial role in regulating gene transcription through epigenetic interactions between bromodomains and acetylated histones during cellular proliferation and differentiation processes.

References:

[1]. Yasushi Taniguchi, et al. The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins. Int J Mol Sci. 2016 Nov 7;17(11):1849. [Content Brief]

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