Thioredoxin, mitochondrial

Definition:

Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.

References:

[1]. Eliska Holzerova, et al. Human thioredoxin 2 deficiency impairs mitochondrial redox homeostasis and causes early-onset neurodegeneration. Brain. 2016 Feb;139(Pt 2):346-54. [Content Brief]

[2]. Anastasios E Damdimopoulos, et al. Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death. J Biol Chem. 2002 Sep 6;277(36):33249-57. [Content Brief]

[3]. Yan Chen, et al. Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells. J Biol Chem. 2002 Sep 6;277(36):33242-8. [Content Brief]

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