Threonine--tRNA ligase, mitochondrial

Definition:

Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain.

References:

[1]. Yong Wang, et al. A Human Disease-causing Point Mutation in Mitochondrial Threonyl-tRNA Synthetase Induces Both Structural and Functional Defects. J Biol Chem. 2016 Mar 18;291(12):6507-20. [Content Brief]

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